Strategies for reducing the dosing interval of orally absorbed drugs rely on changing the release pattern of the drug from the delivery system so that the blood level profile of the drug falls within the therapeutic window overthe time of the dosing interval. however, for drugs that exhibit… More

A novel principle for simultaneous scintillation counting of multiple radioactive samples is proposed. the immediate goal of this proposal is to construct and test a six-sample prototype device to prove the practical applicability of the principle involved. the long-term goal is to develop a device… More

The long-term objective is to develop an oral drug delivery strategy and technology base to increase the extent of absorption and decrease the variability of the absorption of nucleotide antiviral drug analogs in humans. 2', 3'-dideoxyinosine (videx tm, ddi) is a purine nucleosidedrug analog that is… More

About five million americans suffer from genital herpes, with an estimated one-half million individuals having become infected in 1981 alone. although many forms of therapy have been tested, none has proven profoundly beneficial in decreasing the severity and frequency of the clinical… More

Inflammatory bowel disease (IBD) is a collective term that includes Crohn's disease andulcerative colitis. Although both disorders have a distinct clinical course with characteristicpathophysiology, the destructive and progressive course of IBD probably is due to persistent elevatedexpression of… More

Conventional methods of immunization in general require multiple injections at certain intervals to achieve the required protective immune response. However, this immunization protocol may not always be practical, especially for Army personnel in the field or in remote areas where access to the… More

Gliomas are the most common primary intracranial brain tumors and are thought to arise as a neoplastransformation of glial cells in the central nervous system. The prognosis for the disease is poor.surgical resection of the tumor followed by radiation or chemotherapy. This application describes… More

Not Available This Phase I SBIR proposal is aimed at developing a design capability and comprehensive set of simulation tools for exploring the feasibility and making a realistic assessment of the potential for advanced rocket propulsion based on the Pulsed Detonation Engine (PDE) cycle. The PDE is… More

DESCRIPTION (provided by applicant): Recently, it has been shown that a variety of drugs require carrier-mediated transport (e.g., the human dipeptide transporter or hpepT1) in order to cross the cell membrane and be absorbed into the body. Although the use of membrane transporters to enhance drug… More

DESCRIPTION (provided by applicant): Of the numerous biological agents that may be used as weapons, the Working Group on Civilian Biodefense has identified Bacillus anthracis as one of the most serious agents. The most effective defense against this agent on a broad scale is through an aggressive… More

DESCRIPTION (provided by investigator): With recent unsettling events foreshadowing an increased sense of urgency, NIAID has targeted research and development of therapeutics, vaccines, adjuvants/immunostimulants, and diagnostics for small pox and other viral diseases. At TSRL, Inc., we have been… More

DESCRIPTION (provided by applicant): The hypothesis of this proposal is that the di- or tri-peptide transporter in the gastrointestinal tract can be used as a means to absorb orally delivered peptides as therapeutics in vivo. Recent information indicates that the bradykinin breakdown product of… More

DESCRIPTION (provided by applicant): The long term objective of the project is to develop an orally bioavailable drug for treatment of individuals with acute coronary syndromes (ACS) and also individuals whose cancer is influenced by the mitogenic effects of thrombin. Current therapy for the acute… More

DESCRIPTION (provided by applicant): With the concern for an avian influenza pandemic increasing, there is a need to develop antiviral therapies with improved bioavailability. We are developing an enhanced oral delivery platform for anionic small molecule antiviral drugs using zanamivir as our… More

DESCRIPTION (provided by applicant): With recent unsettling events foreshadowing an increased sense of urgency, NIAID has targeted research and development of therapeutics, vaccines, adjuvants/immunostimulants, and diagnostics for smallpox (variola). TSRL was granted a Phase I SBIR to explore… More

DESCRIPTION (provided by applicant): The Working Group for Civilian Biodefense has identified smallpox as one of the most serious biological agents that could cause disease and deaths in sufficient numbers to cripple a city or region. The National Institut e of Allergy and Infectious Disease has… More

DESCRIPTION (provided by applicant): Bisphosphonates are chemically and enzymatically stable analogues of inorganic pyrophosphate that interfere with specific biochemical and enzymatic pathways of the bone-resorbing osteoclasts. The development of the bisp hosphonates has yielded effective… More

DESCRIPTION (provided by applicant): A major limitation with most current medical therapies for inflammatory bowel disease (IBD) is the indiscriminant immunosuppressive effect of these drugs. We have recently demonstrated the ability to palliate the progre ssion of colitis in a mouse dextran sodium… More

DESCRIPTION (provided by applicant): Virally-encoded neuraminidase plays a key role in the life-cycle of the influenza virus. A class of anti-influenza drugs that inhibits the action of neuraminidase has garnered increasing interest in the pharmaceutical i ndustry due to their selectivity and… More

DESCRIPTION (provided by applicant): As a result of the widespread use of antiviral prophylaxis and pre-emptive therapy, the incidence and severity of human cytomegalovirus (HCMV) disease and its indirect effects have been significantly reduced. However, t here is an increasing recognition of… More

DESCRIPTION (provided by applicant): A major limitation with most current medical therapies for inflammatory bowel disease (IBD) is the indiscriminant immunosuppressive effect of these drugs. We have recently demonstrated the ability to palliate the progre ssion of colitis in a mouse dextran sodium… More

DESCRIPTION (provided by applicant): Virally-encoded neuraminidase plays a key role in the life-cycle of the influenza virus. A class of anti-influenza drugs that inhibits the action of neuraminidase has garnered increasing interest in the pharmaceutical industry due to their selectivity and… More