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DESIGN AND EVALUATION OF A COMPOUND TRACHEAL PROSTHESIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7221
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
7221
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Utah Biomedical Test Labs
520 Wakara Way Salt Lake, UT 84108
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1988
Title: DESIGN AND EVALUATION OF A COMPOUND TRACHEAL PROSTHESIS
Agency: HHS
Contract: N/A
Award Amount: $453,000.00
 

Abstract:

THE PROPOSED STUDY IS DESIGNED TO DEVELOP AND EVALUATE A METHOD OF REPLACING THE TRACHEA WITH A COMPOUND PROSTHESIS THAT WILL BE EPITHELIZED AT THE TIME OF IMPLANTATION BY TISSUE CULTURE OF BUCCAL MUCOSA OR A FREE GRAFT OF TRACHEAL MUCOSA. HEALING OF THE CERVICAL TRACHEA TO TWO TYPES OF PROSTHESES WILL BE EVALUATED IN DOGS. BOTH TYPES WILL HAVE A RIGID POLYETHYLENE OUTER LAYER AND A MIDDLE LAYER OF ATELOCOLLAGEN. THE INNER LAYER, OR TYPE 1 PROSTHESIS, WILL CONSIST OF BUCCAL MUCOSAL TISSUE CULTURED ONTO THE COLLAGEN LAYER. THE TYPE 2 PROSTHESIS WILL HAVE A FREE GRAFT OF TRACHEAL MUCOSA. THE PROSTHESES WILL BE EVALUATED AT VARIOUS POSTIMPLANTATION TIMES OF UP TO 60 DAYS. EVALUATIONOF THE SURGICAL SITES FOR GRAFTED AND CULTURED MUCOSAL HEALING, PROLIFERATION, CONNECTIVE TISSUE GROWTH, SCARRING, INFECTION, AND REJECTION WILL BE PERFORMED BY GROSS EXAMINATION AND HISTOPATHOLOGICAL METHODS.

Principal Investigator:

Richard E Hoffer Dvm
8015833600

Business Contact:

Small Business Information at Submission:

Ubtl Inc.
520 Wakara Way Salt Lake City, UT 84108

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No