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Real Time Monitoring of Signaling Pathways in Biological Cells

Award Information

Agency:
Department of Defense
Branch:
Defense Advanced Research Projects Agency
Award ID:
68790
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
04SB1-0236
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
UES, Inc.
4401 Dayton-Xenia Road Dayton, OH -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Real Time Monitoring of Signaling Pathways in Biological Cells
Agency / Branch: DOD / DARPA
Contract: W31P4Q-04-C-R207
Award Amount: $98,917.00
 

Abstract:

Signaling pathways in cells historically have been studied using in vitro assays, where components are purified from cells and the reactions are done in a test tube. These assays can be helpful in identifying key players of signaling pathways, however these in vitro assays cannot mimic the complex environment and interactions found in the cytoplasm of an intact cell. Several important signaling pathways involved in maintaining healthy tissue and preventing disease are the kinases, which phosphorylate proteins in response to specific upstream signals. Recent advances in nanoparticle technology are starting to make visualization of cellular events in vivo, in real time, possible. We propose to use two different bioconjugated nanoparticles (BNPs) to visualize and localize kinase activity, using one BNP, and, with the second BNP, we will specifically inhibit kinase activity and release that inhibition with a specific, external signal.

Principal Investigator:

Melanie Tomczak
Research Scientist
9374266900
mtomczak@ues.com

Business Contact:

Francis F. Williams
Contracts Manager
9374266900
fwilliams@ues.com
Small Business Information at Submission:

UES, INC.
4401 Dayton-Xenia Road Dayton, OH 45432

EIN/Tax ID: 310797776
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No