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MICROELECTRODES FOR THE DETERMINATION OF NEUROREGULATORS

Award Information

Agency:
Department of Health and Human Services 		Branch:
N/A 		Award ID:
14004 		Program Year/Program:
1991 / SBIR
Agency Tracking Number:
14004 		Solicitation Year:
N/A 		Solicitation Topic Code:
N/A 		Solicitation Number:
N/A
Small Business Information
Universal Sensors, Inc.
5258 Veterans Blvd., Suite D Metairie, LA 70006
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1991
Title: MICROELECTRODES FOR THE DETERMINATION OF NEUROREGULATORS
Agency: HHS
Contract: N/A
Award Amount: $323,579.00
 

Abstract:

OVER THE LAST 20 YEARS, MANY NEUROREGULATORS HAVE BEEN IDENTIFIED AND SIGNIFICANT PROGRESS HAS BEEN MADE IN IDENTIFYING THE MOLECULAR BASIS OF NEUROTRANSMISSION. THE IN VIVO DYNAMICS OF SEVERAL NEUROCHEMICAL EVENTS HAVE BEEN MONITORED USING AMPEROMETRIC MICROELECTRODES, BUT THIS APPROACH IS HINDERED BY THE REALTIVELY POOR SELECTIVITY OF THESE ELECTRODES. IN THIS PROJECT, ELECTRODES WITH EXCELLENT SELECTIVITIES WILL BE DEVELOPED BY INCORPORATING A THIN LAYER OF IMMOBILIZED ENZYME AND OTHER PROTECTIVE COATINGS INTO THE MICROELECTRODE. SUCH ELECTRODES WOULD ALLOW THE IN VIVO DETERMINATION OF NONELECTROACTIVE SPECIES FOR THE FIRST TIME. INITIALLY, AN ELECTRODE FOR THE DETERMINATION OF THE POTENT NEUROEXCITATORY AMINO ACID, GLUTAMATE, WAS DEVELOPED, BECAUSE IT HAS BEEN IDENTIFIED IN MANY NEURONAL PATHWAYS ANDIS NORMALLY PRESENT IN FAIRLY HIGH CONCENTRATIONS. THE SPATIAL, TEMPORAL, AND ANALYTICAL CHARACTERISTICS OF THE ELECTRODES WILL BE IMPROVED, AND MICROELECTRODES FOR OTHER COMPOUNDS IMPORTANT IN NEUROREGULATION WILL BE DEVELOPED IN PHASE II.

Principal Investigator:

Glenn J Lubrano
5048858443

Business Contact:

Small Business Information at Submission:

Universal Sensors Inc.
Po Box 736 New Orleans, LA 70148

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No