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HIV SCREENING AID FOR MEDICAL PRACTICE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16294
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
16294
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
University Park Pathology Assc
1408 W University Ave Urbana, IL 61801
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1991
Title: HIV SCREENING AID FOR MEDICAL PRACTICE
Agency: HHS
Contract: N/A
Award Amount: $49,690.00
 

Abstract:

THOUGH THE PERFORMANCE CHARACTERISTICS OF TEST SEQUENCES FOR HIV INFECTION ARE AMONG THE BEST TO BE FOUND IN CLINICAL LABORATORY PRACTICE, LARGE SCALE SCREENING COMBINED WITH LOW PREVALENCE RESULTS IN SIGNIFICANT PERSONAL AND SOCIAL COSTS IN TERMS OF EMPLOYABILITY AND INSURABILITY, AND HENCE CARRY MAJOR LIABILITY IMPLICATIONS. A MAJOR COMPONENT PROBLEM IS THE PARTIAL PATTERN MATCHING OFTEN INVOLVED IN INTERPRETATION OF THE WESTERN BLOT CONFIRMATORY TEST. IN THESE TESTS, REPORTING PROTOCOLS CONTINUE TO BE IDIOSYNCRATIC AND ARE SOMETIMES COMPLETELY INCORRECT. FURTHERMORE, A SMALL PROPORTION OF TEST RESULTS, BUT SIGNIFICANT IN TERMS OF ABSOLUTE NUMBERS, CAN ONLY BE CHARACTERIZED AS INDETERMINATE AT ANY ONE TIME. THE POSITIVE OR NEGATIVE PREDICTIVE POWER OF SUCH A RESULT IS VERY SENSITIVE TO TEST OPERATING CHARACTERISTICS IN A PARTICULAR LABORATORY SETTING AND TO THE A PRIORI PROBABILITIES DETERMINED BY THE HISTORY OF RISK BEHAVIOR. WE PLAN TO EXPLORE THE DEVELOPMENT OF SOFTWARE, FOR THE CLINICAL LABORATORY OR THE PRACTITIONER'S OFFICE, TO PROPOSE EPIDEMIOLOGICALLY SOUND PREDICTIVE INFERENCES FROM ALL REPORTED COMBINATIONS OF RESULTS FROM HIV TEST SEQUENCES, INCORPORATING ADJUSTMENTS FOR RISK GROUP AND REGIONAL SEROPREVALENCE. THIS PACKAGE IS TO INCLUDE, AT THE LEAST VERSIONS FOR MS-DOS AND MACINTOSH PLATFORMS.

Principal Investigator:

Williams, Ben T
Principal Investigator
2173372323

Business Contact:

1 r43 ai30865-01
Small Business Information at Submission:

University Park Pathology Asso
1408 West University Avenue Urbana, IL 61801

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No