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Company Information:

Company Name: VALA SCIENCES, INC.
City: SAN DIEGO
State: CA
Zip+4: 92121-
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $2,716,478.00 6
SBIR Phase II $2,695,199.00 3
STTR Phase I $1,277,609.00 6
STTR Phase II $5,183,866.00 4

Award List:

HT Image Assay of Lipid Droplet Formation in Human Adipocytes

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Patrick M. Mcdonough
Award Amount: $142,606.00
Abstract:
DESCRIPTION (provided by applicant): Obesity is an increasing health problem in the US, as it limits mobility and is an independent contributing factor to the development of diabetes and heart disease. Therefore, there is likely to be an ever increasing demand for Pharmaceuticals that may modulate… More

Live cell and HCS assays to quantify production of cardiomyocytes from stem cells

Award Year / Program / Phase: 2007 / STTR / Phase II
Agency: HHS
Research Institution: N/A
Principal Investigator: Patrick M. Mcdonough
Award Amount: $1,305,875.00
RI Contact: N/A
Abstract:
DESCRIPTION (provided by applicant): Heart failure is a leading cause of mortality in modern society, and is the result from the death of cardiac myocytes. Contractile function of failing hearts can be restored by injecting the heart with embryonic stem ce ll-derived cardiac myocytes (ESCMs) which… More

HT Image Assay of Lipid Droplet Formation in Human Adipocytes

Award Year / Program / Phase: 2008 / SBIR / Phase II
Agency: HHS
Principal Investigator: Patrick M. Mcdonough
Award Amount: $934,943.00
Abstract:
DESCRIPTION (provided by applicant): Obesity is an overwhelming problem in Western Society, as approximately 30% of the American adult population is overweight. Obesity is dangerous not only because of the increased metabolic costs associated with overall motility, but also because it is a strong… More

Automated analysis of skeletal muscle fiber crossectional area and metabolic type

Award Year / Program / Phase: 2008 / STTR / Phase I
Agency: HHS
Research Institution: N/A
Principal Investigator: Patrick M. Mcdonough
Award Amount: $153,853.00
RI Contact: N/A
Abstract:
DESCRIPTION (provided by applicant): The accurate quantification of skeletal muscle morphology is desired by researcher investigating a wide variety of health issues such as aging, muscle denervation, muscle regeneration, muscular dystrophy, exercise p hysiology, nutrition, and space flight. For… More

Automated quantification of lipid droplets in fatty liver tissue sections

Award Year / Program / Phase: 2008 / STTR / Phase I
Agency: HHS
Research Institution: N/A
Principal Investigator: Patrick M. Mcdonough
Award Amount: $151,754.00
RI Contact: N/A
Abstract:
DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is emerging as a health crisis and is caused by the accumulation of lipid within liver cells (hepatocytes). The disease is similar to alcoholic liver disease, as lipid droplets (steatosis) appear first, followed by… More

A New Toxicity Screen to Assess Mitochondrial DNA Content and Protein Synthesis

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: HHS
Principal Investigator: Ross J. Whittaker
Award Amount: $270,126.00
Abstract:
DESCRIPTION (provided by applicant): Investment in research and development by pharmaceutical companies has more than tripled since the early 1990's, but the number of the new molecular entity (NME) approvals has remained stagnant. The industry is still pl agued by costly late stage attrition in… More

Not Available

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: HHS
Principal Investigator: Emily Arsenault
Award Amount: $880,128.00
Abstract:
Not Available

Automated Analysis of Skeletal Muscle Fiber Cross-sectional Area and Metabolic Ty

Award Year / Program / Phase: 2011 / STTR / Phase II
Agency: HHS
Research Institution: INDIANA UNIVERSITY
Principal Investigator: Patrick M. Mcdonough – 858-461-6863
Award Amount: $1,188,087.00
RI Contact:
Abstract:
DESCRIPTION (provided by applicant): The accurate quantification of skeletal muscle morphology is desired in a wide variety of medical areas such as muscle regeneration, muscular dystrophy, exercise physiology, and nutrition. For such studies, skeletal muscle is often fixed, sectioned, and labeled… More

Automated quantification of lipid droplets in fatty liver tissue sections

Award Year / Program / Phase: 2011 / STTR / Phase II
Agency: HHS
Research Institution: UNIVERSITY OF CALIFORNIA
Principal Investigator: Patrick M. Mcdonough – 858-461-6863
Award Amount: $1,458,397.00
RI Contact:
Abstract:
DESCRIPTION (provided by applicant): NonAlcoholic Fatty liver is associated with obesity, and HCV infection, and is a leading cause of fibrosis, cirrhosis, and liver cancer. Lipid droplet formation (steatosis) is an underlying cause of the pathologies. However, there is considerable variation in the… More

TAS::75 0849::TAS RandD-OTHER SCIENCES-B RES

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Patrick Mcdonough – 858-461-6861
Award Amount: $1,730,100.00
Abstract:
Breast cancer is a devastating affliction in Western Society. It is of high interest to quantify the expression of HER2/neu (a growth factor receptor), the estrogen receptor (ER), and the progesterone receptor (PR) in breast cancer tumors since HER2/neuexpression is associated with high malignancy… More

TAS::75 0849::TAS SBIR TOPIC 277 - AN AUTOMATED KARYOMETRIC ASSAY TO PREDICT RESPONSE TO DRUGS THAT REDUCE THE RISK OF BREAST CANCER

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Patrick Mcdonough – 858-461-6861
Award Amount: $199,260.00
Abstract:
This SBIR contract project will be a collaboration between Vala Sciences Inc, a San Diego-based small business that specializes in the development of quantitative microscopy assays, and the Arizona Cancer Center, whose researchers are the developers of karyometry, an extremely sensitive, but… More

TAS::75 0872::TAS SBIR PHASE II: VALA SCIENCES, TOPIC #44, DEVELOPMENT OF CELL-BASED BIOASSAYS USING IPS CELL LINES

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: HHS
Principal Investigator: Emily Arsenault – 858-461-6861
Award Amount: $880,128.00
Abstract:
Cardiotoxicity is a major concern to pharmaceutical industry and regulatory agencies. Drugs are continuously removed from the market because of their toxic effects. To avoid cardiovascular side effects, regulatory agencies generated guidelines describing preclinical investigations to be performed… More

Optogenetic Multiparametric Assay for HT Cardiotoxicity Testing

Award Year / Program / Phase: 2012 / STTR / Phase I
Agency: HHS
Research Institution: INDIANA STATE UNIVERSITY
Principal Investigator: Fabio Cerignoli – 858-461-6859
Award Amount: $221,765.00
RI Contact:
Abstract:
DESCRIPTION (provided by applicant): Monitoring physiology of individual cardiomyocytes in high throughput has not been reported. The inability to perform high throughput physiological measurements limits many basic and applied studies, including the use of stem cell derived cardiomycoytes in… More

Kinetic image cytometry assays for neuronal activity/toxicity

Award Year / Program / Phase: 2013 / STTR / Phase I
Agency: HHS
Research Institution: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Principal Investigator: Patrick M. Mcdonough – 858-461-6863
Award Amount: $300,000.00
RI Contact:
Abstract:
DESCRIPTION (provided by applicant): The proposed project is a Phase I STTR collaboration between Vala Sciences Inc, a small business that specializes in the development of cell-based high content/high throughput assays, and the Sanford Burnham Medical Research Institute, a worldwide leader in… More

Optogenetic Multiparametric Assay for HT Cardiotoxicity Testing

Award Year / Program / Phase: 2013 / STTR / Phase II
Agency: HHS
Research Institution: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
Principal Investigator: Fabio Cerignoli – 858-461-6859
Award Amount: $1,231,507.00
RI Contact:
Abstract:
DESCRIPTION (provided by applicant): Monitoring physiology of individual cardiomyocytes in high throughput has not been reported. The inability to perform high throughput physiological measurements limits many basic and applied studies, including the use of stem cell derived cardiomycoytes in… More

Association Analysis Software for Mining Clinical Next-Gen Sequencing Data

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Patrick M. Mcdonough – 858-461-6863
Award Amount: $224,549.00
Abstract:
Congenital cardiac defects (CCDs) are among the most common birth defects and fetal cardiac defects likely contribute to miscarriages, which terminate up to 25% of all pregnancies. Environmental factors may influence up to 80% of all CCDs, but little is known about how chemicals from the environment… More

FY-2013 Contract HHSN271201300010C, Topic 004. A High Throughput Assay for Neur

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Patrick Mcdonough – 858-461-6861
Award Amount: $149,837.00
Abstract:
The technical objectives from the original solicitation are presented below, along with a brief discussion relevant to the Neural Crest Cell Migration assay. 1) Develop a working assay in a 384 microwell format (the Phase II objective will be to adapt the assay to the 1536 well format). Cells… More