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Automated quantification of lipid droplets in fatty liver tissue sections

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
89516
Program Year/Program:
2008 / STTR
Agency Tracking Number:
DK082087
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
VALA SCIENCES, INC.
VALA SCIENCES, INC. 6370 NANCY RIDGE DR. SAN DIEGO, CA 92121-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: Automated quantification of lipid droplets in fatty liver tissue sections
Agency: HHS
Contract: 1R41DK082087-01
Award Amount: $151,754.00
 

Abstract:

DESCRIPTION (provided by applicant): Non-alcoholic fatty liver disease (NAFLD) is emerging as a health crisis and is caused by the accumulation of lipid within liver cells (hepatocytes). The disease is similar to alcoholic liver disease, as lipid droplets (steatosis) appear first, followed by damage to the hepatocytes (steatohepatitis), cell death, inflammation, and cirrhosis. Alarmingly, the incidence of NAFLD in the US may be as high as 30% of the general population, and occurs at even higher incidence in patients suffering from obesity, diabetes, and hepatitis C viral infection, indicating that there will soon be a dramatic increase in the rates of liver dysfunction and failure. Researchers world-wide are studying fatty liver in human patients and in a va riety of animal models, using semi-quantitative scoring techniques to estimate the degree of hepatic steatosis. The goal of this Phase I STTR project is to develop image-analysis techniques to quantify the grade of steatosis, percentage of fat, and the fre quency and size of lipid droplets in images obtained from liver biopsies and tissue sections. The proposed algorithm will be particularly useful in recognizing subtle changes in steatosis which are likely to occur in studies utilizing experimental therapeu tics. The algorithm will be developed with images obtained from human liver biopsies by Dr. Zachary Goodman, a leading authority on fatty liver and will provide a new research tool for quantifying steatosis that will be of high interest to researchers in t his critical area of human health. PUBLIC HEALTH RELEVANCE: Fatty liver disease is a condition that affects a high proportion of the US population, particularly people that are overweight or obese. Fatty liver is characterized by the occurrence of fat droplets within the cells that make up the liver. Tissue samples (biopsies) are commonly taken from livers as part of the protocol for research studies on fatty liver disease, and the fat content of the samples are graded by pathologists, using microscopes and somewhat grading criteria, that is, at best, semi-quantitative. The proposed research will develop a technique for rapid and precise automatic quantitation of the fat content of liver biopsies, which will be an aid to workers investigating fatty liver disease.

Principal Investigator:

Patrick M. Mcdonough
8585816275
PMCDONOUGH@VALASCIENCES.COM

Business Contact:


vhilberg@valasciences.com
Small Business Information at Submission:

VALA SCIENCES, INC.
VALA SCIENCES, INC. 3030 BUNKER HILL STREET SAN DIEGO, CA 92109

EIN/Tax ID: 200906350
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No