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In-ovo vaccination/avian influenza/bird/human

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R44AI068285-02
Agency Tracking Number: AI068285
Amount: $955,357.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: PHS2007-2
Timeline
Solicitation Year: 2008
Award Year: 2008
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1500 First Avenue North Suite D126
BIRMINGHAM, AL 35203
United States
DUNS: 032198363
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 () -
Business Contact
Phone: (205) 909-3737
Email: vankampen@vaxin.com
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): The aim of this proposal is to develop an effective and rapid method for disrupting the poultry-to-human transmission of avian influenza by in ovo injection of adenovirus-vectored avian influenza vaccines that can be ma
ss-produced in cultured cells and mass-administered with a mechanized injector. The hypothesis is that mass-vaccination of poultry against an outbreak of avian influenza reduces the dissemination of the virus to new flocks and consequently the risk to huma
ns. As avian influenza gets more and more deadly, it is increasingly urgent to produce vaccines rapidly in response to an unprecedented escalation in demand. We have demonstrated that chickens can be immunized against highly pathogenic avian influenza viru
ses by in ovo administration of non-replicating adenovirus vectors encoding an avian influenza virus hemagglutinin. In contrast to conventional avian influenza vaccines, this new class of avian influenza vaccine does not mask natural infections by an avian
influenza virus. The recombinant adenovirus vector can be rapidly generated using Vaxin's proprietary AdHigh system without the requirement to propagate lethal avian influenza viruses. The Phase II studies will further explore the potential of an adenovir
us-vectored in ovo vaccine in mobilizing the immune repertoire toward a beneficial immune protection against avian influenza in chickens. In this project, the potential for an adenovirus-vectored in ovo avian influenza vaccine to immunize breeder hens and
progeny chickens will be investigated; the fate of adenovirus vectors in chickens following in ovo administration will be determined; vaccination of chickens against multiple avian diseases by adenovirus-vectored in ovo vaccines will be developed; the comp
atibility between an adenovirus-vectored in ovo vaccine and the DIVA strategy for immunization of poultry will be defined; and the potency of adenovirus-vectored in ovo vaccines under field conditions will be analyzed. The overall goal of these experiments
is to develop a new generation of avian influenza vaccine that can be rapidly manufactured and administered for mass-immunization of poultry in response to a crisis. PUBLIC HEALTH RELEVANCE: Avian influenza represents a major impending threat to public he
alth. Mass-vaccination of poultry flocks against this deadly disease will be a crucial tool for reducing the rapid spread of the anticipated human pandemic. Vaccinating eggs before they hatch is much faster, easier, and less expensive than vaccinating live
birds. The aim of this proposal is to develop a safe and effective vaccine which can rapidly vaccinate eggs to stop or slow the spread of the avian influenza, thus protecting humans as well as a significant food source. A genetically modified adenovirus i
s the basis of this new type of vaccine.

* Information listed above is at the time of submission. *

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