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THE ABILITY OF SELECTED SILICONE-BASED POLYMERS TO DISSOLVE HUMAN CHOLESTEROL…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
1381
Program Year/Program:
1984 / SBIR
Agency Tracking Number:
1381
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Ventec Laboratories Inc.
2284 Enterprise Drive Nt. Pleasant, MI 48858
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1984
Title: THE ABILITY OF SELECTED SILICONE-BASED POLYMERS TO DISSOLVE HUMAN CHOLESTEROL AND BILIRUBINATE GALLSTONES IN VIVO WILL BE ASSESSED.
Agency: HHS
Contract: N/A
Award Amount: $20,740.00
 

Abstract:

THE ABILITY OF SELECTED SILICONE-BASED POLYMERS TO DISSOLVE HUMAN CHOLESTEROL AND BILIRUBINATE GALLSTONES IN VIVO WILL BE ASSESSED. GALLSTONES WILL BE CATAGORIZED AS PREDOMINATELY CHOLESTEROL TYPE OR BILIRUBIN TYPE BASED ON COLOR. WEIGHT-MATCHED SETS OF FOUR STONES WILL BE INCUBATED IN BUFFER, SODIUM CHOLATE, MONOOCTANOIN AND IN A SERIES OF SILICONE-BASED POLYMERS. WEIGHT LOSS WILL BE FOLLOWED FOR A PERIOD OF UP TO THREE WEEKS. ANY POLYMER WHICH COMPARES FAVORABLY TO MONOOCTANOIN WITH REGARD TO THE DISSOLUTION RATE FOR CHOLESTEROL STONES WILL BE SUGGESTED AS A CANDIDATE FOR PHASE II STUDY. POLYMERS THAT DISSOLVE BILIRUBINATE STONES AT ANY RATE WILL BE CONSIDERED CANDIDATES FOR PHASE II STUDY. ONE POLYMER HAS BEEN SHOWN TO PROMOTE THE DISSOLUTION OF BOVINE BILIRUBINATE STONES IN A BRIEF IN VITRO EXPERIMENT. PHASE II RESEARCH WILL BE DIRECTED TOWARD PRECLINICAL QUALIFICATION SUFFICIENT TO WARRENT IND INVESTIGATION OF A SAFE POLYMERIC SOLVENT FOR BILIRUBINATE STONES THAT IS COMPATIBLE WITH MONOOCTANOIN. SUCH A MIXED SOLVENT HAS POTENTIAL TO DISSOLVE ALL RETAINED GALLSTONES. FOLLOW-ON FUNDING WILL BE EVALUATED AS SOON AS A POLYMER IS IDENTIFIED THAT MEETS THE DEVELOPMENT SELECTION CRITERIA.

Principal Investigator:

Robert r. levier
VICE PRESIDENT
0

Business Contact:

Small Business Information at Submission:

Ventec Laboratories Inc.
2284 Enterprise Drive Nt. Pleasant, MI 48858

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No