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Lactoferrin prevents biofilm formation at wound

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
75846
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
AG026206
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
VENTRIA BIOSCIENCE
320 East Vine Drive FORT COLLINS, CO -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Lactoferrin prevents biofilm formation at wound
Agency: HHS
Contract: 1R43AG026206-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): Wound healing is a major health issue for the elderly. Biofilm development at the wound site renders many existing treatments ineffective in treating wound pathogens because when bacteria is protected by biofilm it increases its resistance to antibiotics. Bacteria protected by biofilm demonstrate a 100 to 1000 fold increase in resistance to antibiotics. Recent research has shown that human lactoferrin is effective in preventing biofilm formation. Production of recombinant human lactoferrin (rhLF) in rice grain provides the foundation for large quantities of raw material at an affordable cost. A rhLF-based treatment to enhance wound healing is proposed. In phase I, rice grain will be scaled up and a process to efficiently purify lactoferrin from rice grain will be developed. This procedure will be used to prepare quality rhLF, which would then be used to test rhLF's effect on biofilm formation for various bacterial strains isolated from wound site including antibiotic resistant strains.

Principal Investigator:

Ning Huang
9169216148
NHUANG@VENTRIA.COM

Business Contact:


9169216148
Small Business Information at Submission:

Ventria Bioscience
Ventria Bioscience 4110 N Freeway Blvd Sacramento, CA 95834

EIN/Tax ID: 680310843
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No