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Expression of Human Transferrin in Rice Grain

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
93810
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
GM086916
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
VENTRIA BIOSCIENCE
320 East Vine Drive FORT COLLINS, CO -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: Expression of Human Transferrin in Rice Grain
Agency: HHS
Contract: 1R43GM086916-01
Award Amount: $119,592.00
 

Abstract:

DESCRIPTION (provided by applicant): Transferrin is an essential ingredient used in cell culture media due to its crucial role in regulating cellular iron uptake, transport, and utilization, and also a promising drug carrier to increase drug therapeutic in dex via its unique transferrin receptor-mediated endocytosis pathway. Transferrin currently in use is made mainly from blood plasma, and thus it carries a high risk of contamination with blood-borne pathogens while facing blood supply shortage. Recombinant production of transferrin protein is ideally situated to address both the safety concern and shortage problem of native transferrin for use in cell culture and drug delivery markets. Currently only limited quantity of yeast cell-expressed recombinant huma n transferrin is available at an extremely high price in the cell culture market. Ventria Bioscience already has produced the human lactoferrin, a close relative to human transferrin, in rice grains on large scale and at low lost. In this proposal, we plan to exploit similar technology used for large scale production of lactoferrin to express human transferrin in rice grains. The proposed studies will develop stable transgenic rice lines expressing recombinant human transferrin as a safe and low cost altern ative to human blood derived transferrin for use in biopharmaceutical cell culture and drug delivery markets. Public Health Relevance: Transferrin plays a crucial role in regulating iron and is an essential ingredient used in cell culture medium and a pote ntial candidate for drug conjugates. Transferrin used in cell culture is currently made from blood plasma, and thus carries a high risk of contamination with pathogens. Development of an affordable animal free source of recombinant human transferrin would enable safe large scale use of transferrin in cell culture and drug conjugates.

Principal Investigator:

Deshui Zhang

Business Contact:

Ning Huang
nhuang@ventria.com
Small Business Information at Submission:

VENTRIA BIOSCIENCE
2120 MILESTONE DRIVE SUITE 102 FORT COLLINS, CO 80525

EIN/Tax ID: 680310843
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No