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LIPOSOMAL GOLD COMPOUNDS\IMPROVED ANTIARTHRITIC THERAPY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16355
Program Year/Program:
1991 / SBIR
Agency Tracking Number:
16355
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Vestar, Inc.
650 Cliffside Drive San Dimas, CA 91773
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1991
Title: LIPOSOMAL GOLD COMPOUNDS\IMPROVED ANTIARTHRITIC THERAPY
Agency: HHS
Contract: N/A
Award Amount: $46,571.00
 

Abstract:

CONJUGATED GOLD COMPOUNDS SUCH AS AUROTHIOMALATE, ARE ADMINISTERED IN PROGRESSIVE RHEUMATOID ARTHRITIS. AT PRESENT, ONLY THESE ANTIARTHRITICS ARREST THE PROGRESSION OF THE DISEASE. TREATMENT IS LIMITED BECAUSE SEVERE ORGAN TOXICITIES OCCUR IN 33% OF PATIENTS TAKING PARENTERAL OR ORAL GOLD COMPOUNDS. IT IS PROPOSED THAT AUROTHIOMALATE OR AUROTHIOGLUCOSE ENCAPSULATED INTO THE INTERNAL AQUEOUS SPACE OF UNILAMELLAR PHOSPHOLIPIDS VESICLES (LIPOSOMES) WOULD BE A MORE EFFECTIVE FORM OF THE DRUG BECAUSE TOXICITY WOULD BE REDUCED. IT IS FURTHER PROPOSED THAT THE DRUG WOULD BE DELIVERED TO LYMPHOCYTES FOUND IN THE SYNOVIUM AND INHIBIT THE PRODUCTION OF INFLAMMATORY MEDIATORS BY THESE CESS. THIS STUDY WILL INVOLVE THE PREPARATION OF GOLD COMPOUNDS INTO SMALL UNILAMELLAR VESICLES, EVALUATION OF THESE FORMULATIONS FOR STABILITY AND IN VITRO ACTIVITY, AND TESTING OF APPROPRIATE FORMULATIONS IN TYPE II COLLAGEN INDUCED ARTHRITIS MODEL IN MICE. DEVELOPMENT OF THIS DRUG DELIVERY SYSTEM WOULD EXTEND VESTAR'S TECHNOLOGY BASE BY THE DEVELOPMENT OF A LIPOSOME DRUG DELIVERY SYSTEM FOR WATER SOLUBLE ANTIINFLAMMATORY AGENTS.

Principal Investigator:

Konigsberg, Paula J
Principal Investigator
7143944000

Business Contact:

1 r43 ar41094-01
Small Business Information at Submission:

Vestar, Inc
650 Cliffside Drive San Dimas, CA 91773

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No