This proposal is for the fabrication of a thermal spray device to couple a high pressure liquid chromatography (hplc) and a mass spectrometer. it is to be demonstrated that the thermal spray mass spectrometer combination will be a universal detector for hplc. phase i is for the development of a… More

The overall objectives of the proposed research are to develop a simplified, inexpensive mass selective detector for high-performance liquid chromatography (hplc) and to demonstrate the utility of this system for solution of significant biomedical problems. specific objectives of this phase i… More

The goal of this research is to develop and adapt vestec corporation's "universal interface" to couple conventional high-performance liquid chromatography (hplc) to electrospray mass spectrometry. the interface, which has been successfully applied to coupling reversed-phase hplc at flow rates as… More

The long-term aims of this project are to create and commercialize a new family of interfaces between chromatography and mass spectrometry that provide multichannel element-and isotope-selective detection capabilities. the approach is based on coupling a new thermospray "universal interface"… More

The overall goal of this project is to develop a high-speed automated protein sequencer employing high-performance packed capillary lc separation, immobilized enzymes, and electrospray mass spectrometry. this system should provide molecular weight and sequence information using sample amounts in the… More

The overall goal of this project is to develop a new laser desorption time-of-flight (ld/tof) mass spectrometric technique for the determination of metal isotope ratios that can be readily applied to studies of the metabolism of biologically significant bulk and trace elements. the phase i goals of… More