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An Implantable Pacemaker Optimized for Smooth Muscle Stimulation

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
89073
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
DK081217
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
VIRGINIA TECHNOLOGIES, INC.
660 Hunters Place CHARLOTTESVILLE, VA 22911-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: An Implantable Pacemaker Optimized for Smooth Muscle Stimulation
Agency: HHS
Contract: 1R43DK081217-01A1
Award Amount: $99,934.00
 

Abstract:

DESCRIPTION (provided by applicant): The use of a device to electrically stimulate smooth muscle proves particularly useful in clinical applications associated with the gastrointestinal tract. Specifically, electrical stimulation has been shown to be effec tive in the treatment of indications like gastroparesis and obesity. However, the technology surrounding smooth muscle stimulator devices has not been optimized. This can primarily be attributed to a gap in knowledge and research surrounding the response o f smooth muscle to stimulation with various electrical parameters. The long-term objective of this project is to design, build, and commercialize a fully implantable, FDA approved, smooth muscle electrical stimulation device, which incorporates energy savi ng techniques. The specific aim of Phase I is to experimentally determine the optimal electrical pulse waveform type and pulse duration for the energy efficient stimulation of smooth muscle. In Phase II, these parameters will be incorporated into a commerc ial prototype. To accomplish the aim, an in vivo rat study will be performed to determine the electrical stimulation current thresholds for contraction at various durations, using rectangular and exponential waveforms. The minimal energy parameters can the n be derived from this information. PUBLIC HEALTH RELEVANCE: Functional gastrointestinal and motility disorders cause a decreased quality of life in up to 25% of the U.S. population, and are associated with costs of up to 30 billion annually in the U.S. a lone (34). Availability of the proposed energy efficient gastrointestinal electrical stimulation device will help to increase the quality of life associated with gastrointestinal motility disorders.

Principal Investigator:

Business Contact:


Ross@vatechnologies.com
Small Business Information at Submission:

VIRGINIA TECHNOLOGIES, INC.
VIRGINIA TECHNOLOGIES, INC. 500 OLD LYNCHBURG RD, STE A CHARLOTTESVILLE, VA 22903

EIN/Tax ID: 541785431
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No