One of the primary limitations in the use of radioimmunoscintigraphic techniques to detect tumors clinically has been the difficulty in achieving high tumor-to-normal-tissue ratios of bound radioactivity. part of this difficulty arises from the fact that a significant proportion of monoclonal… More

Influenza viruses are major agents of epidemic and pandemic disease with resultant deaths from pneumonia. rapid detection of type a influenza permits administration of amantadine to contacts and prevents unnecessary use of antibiotics. because type a influenza may lead to pneumonia in the elderly,… More

The long range goal of this program is to develop and market mouse antiidiotypic (anti-id) monoclonal antibodies (moab) which bear the internal image of the human high molecular weight-melanoma associated antigen (hmw-maa) for active specific immunotherapy in patients with melanoma. this research… More

The molecular cloning and the expression of the Salmonella typhi (ST) 36 kDal porin in Escherichia coli, the sequence analysis of its gene, the preparation of monoclonal antibodies against this antigen, and immunoblots and radioimmunoprecipitations assays of labeled ST whole cells have indicated… More

Early diagnosis and treatment of Lyme disease is associated with an improved clinical outcome,and is recommended to prevent subsequent manifestations such as arthritis and cranial paralysis.Unfortunately, early diagnosis of Lyme disease has been hampered because B.burgdorferi antigens andthe human… More