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Genetically Defined Attenuated Living Vaccine for Francisella

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
85296
Program Year/Program:
2007 / STTR
Agency Tracking Number:
AI072906
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
VIROGENOMICS, INC.
12909 SW 68th Parkway TIGARD, OR 97223-8387
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: Genetically Defined Attenuated Living Vaccine for Francisella
Agency: HHS
Contract: 1R41AI072906-01A1
Award Amount: $588,104.00
 

Abstract:

DESCRIPTION (provided by applicant): Tularemia is the severe and sometimes fatal disease caused by infection with Francisella tularensis. These bacteria are some of the most virulent pathogens known, requiring inoculation or inhalation with as few as 10 or ganisms to cause disease. Infections can be acquired in a variety of ways: bites from an arthropod vector, skin lesions, ingestion of contaminated food or water, or inhalation of aerosolized particles. Its low infectious dose and relative ease of airborne transmission led to the development of F. tularensis as a biological weapon by several national weapons programs. Because it presents a serious threat to national security, the Centers for Disease Control (CDC) classify F. tularensis as a category A select agent. Despite these criteria, there is no approved tularemia vaccine. The goal of the research described herein is to construct a rationally attenuated living vaccine against tularemia. We will build upon our previous discovery of genes required for viru lence in F. tularemia, mutant derivatives of which provide protection against wild-type challenge in mice. These genes will be deleted, individually and in combinations, in the most virulent subspecies of the organism, resulting in attenuated, non-revertin g, defined strains that do not specify antibiotic resistance. After confirming that these strains protect mice against wild-type challenge, we propose to test the vaccines in a non-human primate model, a necessary step to achieving FDA approval. Tularemia is the severe and sometimes fatal disease caused by infection with Francisella tularensis. Its low infectious dose and relative ease of airborne transmission led to the development of F. tularensis as a biological weapon by several national weapons program s. As there is no approved tularemia vaccine, we seek to develop a live attenuated tularemia vaccine.

Principal Investigator:

Fred L. Heffron
5034946738
HEFFRONF@OHSU.EDU

Business Contact:

Gilbert N. Miller
gil.miller@virogenomics.com
Small Business Information at Submission:

VIROGENOMICS, INC.
VIROGENOMICS, INC. 9020 SW WASHINGTON SQUARE RD TIGARD, OR 97223

EIN/Tax ID: 931319125
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
OREGON HEALTH AND SCIENCE UNIVERSITY
OREGON HEALTH AND SCIENCE UNIVERSITY
3181 SW Sam Jackson Pk Rd
PORTLAND, OR 97239-3098
RI Type: Nonprofit college or university