DESCRIPTION (provided by applicant): Tissue dissociation enzyme (TDE) products have not been improved for over 50 years. "Crude collagenase" products contain collagenases and other proteases used to free cells from collagen rich, extracellular matrix. They are derived from minimally purified… More

DESCRIPTION (provided by applicant): The Edmonton Protocol is a breakthrough in the treatment of adult, type 1 diabetic patients and heralds a new era in transplantation medicine. Edmonton's success rate, as measured by insulin independence > 1 year post transplant, is comparable to whole organ… More

DESCRIPTION (provided by applicant): The quality of tissue dissociation enzymes (TDEs) containing collagenase was critical to the success of the Edmonton Protocol, an islet transplantation procedure that led to successful treatment of adult type 1 diabetic patients who were disabled by refractory… More

DESCRIPTION (provided by applicant): VitaCyte LLC is working to improve tissue dissociation enzymes (TDE) required for the isolation of insulin producing pancreatic islet cells from both human and porcine organs. Transplantation of islets into Type 1 Diabe tic patients represents a promising therapy… More

DESCRIPTION (provided by applicant): The demonstration by the Edmonton group that human islet transplantation can be successfully used to manage adult type 1 diabetes patients with refractory hypoglycemia has led to increased funding of clinical trials andfurther research to extend the scope of this… More