DESCRIPTION (provided by applicant): In this proposal, we will design and test a new and useful nanodevice - a fluorescent molecular oscillator. We will develop an application for this device as an ultra-fast nanosensor for detection of DNA damage and apop tosis in cell suspensions. The sensor is… More

DESCRIPTION (provided by applicant): Assay for detection of early stage apoptosis Abstract Detection of the early stages of apoptosis is of critical importance in many fields of biomedical research enterprise and especially in the development of the new dr ugs and therapeutic interventions. The… More

DESCRIPTION (provided by applicant): PEI-somes and cationization of protein probes for microimaging of nervous system In this proposal we will develop a technology and a carrier for the delivery of fluorescently labeled fully functional antibodies into liv e cells. This will make possible… More

DESCRIPTION (provided by applicant): In situ assay for DNA cleavage by topoisomerase II Abstract The goal of the proposed research is to introduce an enabling technology and the first in situ assay for selective detection of DNA cleavage by topoisomerase II (TOPO II). TOPO II is the critical enzyme… More