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Highly Parallel AIDS Assays Using A Microfluidic Flow Cell Array Integrated with

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
93426
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
AI083117
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Wasatch Microfluidics, LLC
4909 BROWN VILLA COVE SALT LAKE CITY, UT 84123-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: Highly Parallel AIDS Assays Using A Microfluidic Flow Cell Array Integrated with
Agency: HHS
Contract: 1R43AI083117-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): The ultimate goal of this project is to develop a multiplex label free platform for high-throughput HIV specific serum antibody detection of patient samples. To help Wasatch Microfludics reach this ultimate goal, this p roposal will address the feasibility of performing high throughput label free detection of serum antibodies to a variety of HIV proteins through the application of a novel microfluidic spotting technology to available Surface Plasmon Resonance (SPR) array platforms. Specifically, a microfluidic flow cell array will be adapted for work with real world samples such as plasma, serum, and cell lysates. The flow cell array will have 48 channels and address an array of spots designed to support ongoing pre- cli nical trials in non-human primates as well as HIV vaccine trials in humans. The development of a low cost, high throughput, multiplex assay to assess the development of humoral immune responses following vaccine administration is essential for comprehensiv e immunomonitoring. PUBLIC HEALTH RELEVANCE: The successful completion of this proposal will create a dramatic improvement in the ability to conduct multiplex SPR-based assays in drug discovery and proteomic research. On a greater scale, this will lead to improved diagnostic tools and reductions in the cost and time of drug development, by significantly improving the throughput of label free screening.

Principal Investigator:

Bruce Gale
8015855944
BRUCE.GALE@UTAH.EDU

Business Contact:

Josh Eckman
bruce@microfl.com
Small Business Information at Submission:

WASATCH MICROFLUIDICS
4909 BROWN VILLA COVE SALT LAKE CITY, UT 84123

EIN/Tax ID: 830413045
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No