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SCAR TISSUE INHIBITION AROUND SOFT TISSUE IMPLANTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
5008
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
5008
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
WHALEN BIOMEDICAL, INC
11 MILLER ST SOMERVILLE, MA 02143-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1989
Title: SCAR TISSUE INHIBITION AROUND SOFT TISSUE IMPLANTS
Agency: HHS
Contract: N/A
Award Amount: $476,362.00
 

Abstract:

THE OBJECTIVE OF THIS PROGRAM IS THE DEVELOPMENT OF AN IMPROVED MAMMARY PROSTHESIS SIGNIFICANTLY LESS PRONE TO THE MAJOR COMPLICATION OF CURRENT DEVICES: THE FORMATION OF A THICKENED FIBROUS TISSUE CAPSULE AROUND THE IMPLANT. THE BASIC APPROACH IS TO ALTER THE SURFACE MORPHOLOGY OF THE IMPLANT FROM SMOOTH SILICONE RUBBER TO A TEXTURED SURFACE, WHICH PROMOTES TISSUE ADHESION AND ATTACHMENT. THIS SURFACEWILL BE GENERATED BY EXTRUDING SILICONE RUBBER FIBRILS AND FORMING THEM INTO A MATRIX BONDED TO THE EXTERIOR OF THE IMPLANT. BASED ON EXPERIENCE WITH IMPLANTABLE COMPLIANCE CHAMBERS FOR ARTIFICIAL HEART SYSTEMS, SURFACE MORPHOLOGY WAS SHOWN TO BE A MAJOR DETERMINANT OF TISSUE CAPSULE THICK-NESS FORMED AROUND THOSE DEVICES. TEST SPECIMENS OF SMOOTH SILICONE RUBBER, A TEXTURED SURFACE PREVIOUSLY CHARACTER- IZED, AND THE TEXTURED SILICONE RUBBER WILL BE EVALUATED IN VIVO FOR TISSUE CAPSULE THICKNESS AND COMPOSITION HISTOLOGY.OTHER USES FOR THE TECHNOLOGY DEVELOPED INCLUDE IMPROVED COMPLIANCE CHAMBER SYSTEMS, CARDIAC PACEMAKER CASINGS, IMPLANTABLE POLYMERIC DRUG DELIVERY SYSTEMS, OR ANY APPLICA-TION IN WHICH EXCESSIVE SCAR TISSUE FORMATION CAN CAUSE UNDESIRABLE SYMPTOMS OR INTERFERE WITH THE PERFORMANCE OF THE DEVICE.

Principal Investigator:

Robert L Whalen
Principal Investigator
6176613693

Business Contact:

Small Business Information at Submission:

Whalen Biomedical Inc.
5 Howland Street Cambridge, MA 02138

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No