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Novel Medicated Dental Floss for Dental Prophylaxis

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22179
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22179
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
WHALEN BIOMEDICAL, INC
11 MILLER ST SOMERVILLE, MA 02143-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Novel Medicated Dental Floss for Dental Prophylaxis
Agency: HHS
Contract: N/A
Award Amount: $47,129.00
 

Abstract:

The purpose is the development of an improved dental floss incorporating a medicated lubricant for the prevention of gingivitis and other periodontal diseases. Gingivitis is largely caused by bacterial activity. Efforts to control intraoral flora by the use of antimicrobial agents, particularly chlorhexidine compounds, have been promising. By incorporating chlorhexidine compounds in a water soluble dental floss lubricant, the antimicrobial will be deposited directly into the interdental spaces which are most susceptible to disease. The relative ease of use of the system will encourage patient compliance and could offer the possibility of dental prophylaxis in difficult situations such as hospital wards or for military personnel in the field. Several different chlorhexidine compounds with differing solubility rates will be prepared. Growth zone inhibition tests will be performed on the lubricant prepara- tions. Promising preparations will be tested in vitro using tooth models to determine the effectiveness of transfer to the tooth surface and continued activity against oral pathogens. Results of this testing should lead to the selection of a system capable of delivering optimal levels of medication for effective preventive dental care.

Principal Investigator:

Mark A. Bowen
6178684433

Business Contact:

Small Business Information at Submission:

Whalen Biomedical, Inc.
5 Howland Street Cambridge, MA 02138

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No