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Delivery of Vaccines by Biodegradable Polymeric Microcapsules with Bioadherence…

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
28769
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
28769
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
WHALEN BIOMEDICAL, INC
11 MILLER ST SOMERVILLE, MA 02143-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Delivery of Vaccines by Biodegradable Polymeric Microcapsules with Bioadherence Properties
Agency / Branch: DOD / ARMY
Contract: N/A
Award Amount: $69,651.00
 

Abstract:

The objective of this program is to demonstrate the feasiility of using iodegradable polymeric microspheres for the encapsulation of vaccines which would produce effective protection for a minimum duration of one year with a single adminstration. Biodegradable microspheres made from poly (D-lactide co -glycolide) will be used. icrospheres will be prepared to provide release times that will correspond to the booster shot schedule of conventional immunization. The release kinetics of the microspheres will be chacterized in vitro, and the microspheres will be filled with the vaccine to be studied. In the Phase I program, botulinis toxoid vaccine and Clostridium will be tested in vivo to demonstrate the level of immunization produced, with the conventional immunization technique serving as an experimental control. These studies aare designed to demonstrate that the single dose microencapsulated vaccine produces an equivalent degree of protection. A single dose vaccine delivery system has the potential to signifi- cantly redce the cost and logistical complexity of providing routin immunizations for military personnel. Thjese same benefits are true for civilian use, where minimizing the need for patient compliance is a goal as well.

Principal Investigator:

Robert L. Whalen, Ph.d.
6178684433

Business Contact:

Small Business Information at Submission:

Whalen Biomedical, Inc.
5 Howland Street Cambridge, MA 02138

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No