The long-term objectives of this project are to improve optical methods for monitoring membrane potential. present evidence suggests that these methods might be used in two clinical settings: first, to study the generation of arrhythmias and other abnormalities of action potential propagation in the… More

The object of the proposed research project is to create improved noble metal oxide ph electrodes by vacuum sputter- ing. metal and reactive sputtering, used together, offer the investigators the means to create reproducible combinations of surface films so that accurate, fast, and economical… More

The long-term objective of this project is the development of a more accurate and useful instrument with which to perform pneumatic microinjection of fluids in the life sciences and microchemistry. studies will be performed to validate experimental results that indicate the pneumatic injection can… More

This study will develop of microspectrophotometric apparatus with sensitivities orders ofmagnitude greater than heretofore possible. The research project will investigate techniques forfabricating unique capillary cells to be used as microanalytical cuvettes. Experiments will be conductedto confirm… More

In the last several years, nitric oxide (NO) has been shown to be an extremely important biologicalongoing research by many investigators is exploring both its function and possible clinical applicatobjective of this project is to investigate and develop a new and novel chemiluminescence based… More

Nitric oxide (NO) is a free-radical gas that is implicated in many important physiological roles,including such fundamental processes as blood pressure regulation and memory formation. While muchindirect research has been performed on systems that use NO, studies of direct in vivo application ofNO… More

DESCRIPTION (provided by applicant): The proposed research offers an innovative approach to the commercial development of in vivo and in vitro S-nitrosothiols (RSNO) sensors. The design of selective and sensitive RSNO sensors and related instrumentation will be undertaken for a wide range of… More

DESCRIPTION (provided by applicant): The proposed research offers an innovative approach to the commercial development of in vivo and in vitro S-nitrosothiols (RSNO) sensors. The design of selective and sensitive RSNO sensors and related instrumentation will be undertaken for a wide range of… More