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Electrochemical Measurement of S-nitrosothiols

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66467
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
GM062077
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
WORLD PRECISION INSTRUMENTS, INC.
WORLD PRECISION INSTRUMENTS, INC 175 SARASOTA CENTER BLVD SARASOTA, FL 34240-0875
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Electrochemical Measurement of S-nitrosothiols
Agency: HHS
Contract: 2R44GM062077-02
Award Amount: $0.00
 

Abstract:

DESCRIPTION (provided by applicant): The proposed research offers an innovative approach to the commercial development of in vivo and in vitro S-nitrosothiols (RSNO) sensors. The design of selective and sensitive RSNO sensors and related instrumentation will be undertaken for a wide range of biological applications. The use of sensitive nitric oxide electrochemical sensors coupled with a Cu(I) ion generator and delivery system, demonstrates detection of RSNOs in the nanomolar range. The RSNO sensors would offer preferential detection of both low and high molecular weight (protein) RSNOs. The following aims will be pursued in this proposal (1) the RSNO sensor, further combines with HPLC system to separate and detect different RSNOs on line 2) development and commercialization of an electronic controller instrument for use with RSNO sensors, (3) development of new RSNO sensors suitable for biological sampling (4) biological field testing of the RSNO detector and instrumentation. These goals will be reached with significant electroanalytical, bioanalytical development and detailed biological studies. The proposed research will capitalize upon the group's recent advances in NO nanosensors, microchip sensors, and a novel micromixer and Cu(I) generator. The long term goal of the proposed project is to create commercially viable and robust instrumentation with which to measure the concentration of S-nitrosothiols rapidly, selectively and with sensitivity capable of detecting these species in the biologically relevant concentration range.

Principal Investigator:

Xueji Zhang
9413711003
XUEJI@WPIINC.COM

Business Contact:

Mark Broderick
9413711003
MBRODERICK@WPIINC.COM
Small Business Information at Submission:

WORLD PRECISION INSTRUMENTS, INC.
WORLD PRECISION INSTRUMENTS, INC 175 SARASOTA CENTER BLVD SARASOTA, FL 34240

EIN/Tax ID: 060851296
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No