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RAPID BIOASSAY FOR SERUM AND URINE LEVELS OF AZIDOTHYMIDINE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13658
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13658
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Wyatt Technology Corp
820 E Haley St Santa Barbara, CA 93103
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: RAPID BIOASSAY FOR SERUM AND URINE LEVELS OF AZIDOTHYMIDINE
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

AZIDOTHYMIDINE (AZT) IS ONE OF THE MOST EFFECTIVE DRUGS PRESENTLY AVAILABLE FOR ALLEVIATING SOME OF THE SYMPTOMS OF ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) AND DECREASING ITS MORTALITY RATE. RECENTLY, AZT HAS BEEN RECOMMENDED AND APPROVED FOR USE BY HIV-POSITIVE, ASYMPTOMATIC PATIENTS, INCLUDING CHILDREN. HOWEVER, ITS SIDE EFFECTS ARE OFTEN DANGEROUS. ALTHOUGH MUCH HAS BEEN LEARNED ABOUT THE DRUG AND ITS ACTIVITY AS AN ANTIVIRAL AGENT, VERY LITTLE IS KNOWNOF EFFECTIVE SERUM LEVELS OR THE RELATIONSHIP (IF ANY) BETWEEN SERUM LEVELS AND THE THERAPEUTIC INDEX. AT THE PRESENT TIME, ONLY HPLC AND RIA METHODS ARE AVAILABLEFOR MONITORING AZT SERUM LEVELS. THEY ARE RELATIVELY SLOW, EXPENSIVE, LABOR INTENSIVE, AND IMPRACTICAL FOR ROUTINE PHARMACOKINETIC STUDIES. IT IS THE OBJECTIVE OF THIS PROGRAM TO DEVELOP AND REFINE A SIMPLE, INEXPENSIVE, AND RELATIVELY RAPID ASSAY FOR AZT IN HUMAN SERUM, URINE, AND OTHER BODY FLUIDS BY MEANS OF A LASER LIGHT-SCATTERING BIOASSAY.

Principal Investigator:

Philip J Wyatt
8059635409

Business Contact:

Small Business Information at Submission:

Wyatt Technology Corp
820 E Haley St Santa Barbara, CA 93103

EIN/Tax ID: 770027705
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No