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DEVELOPMENT OF HYDROHEPTIN, AN ANTIFUNGAL ANTIBIOTIC

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
19143
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
19143
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
XECHEM, INC.
NEW BRUNSWICK TECHNOLOGY CENTER 100 JERSEY AVENUE, BLDG. B-310 NEW BRUNSWICK, NJ 08901
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1992
Title: DEVELOPMENT OF HYDROHEPTIN, AN ANTIFUNGAL ANTIBIOTIC
Agency: HHS
Contract: N/A
Award Amount: $49,680.00
 

Abstract:

THE INCIDENCE OF FUNGAL INFECTION HAS BEEN STEADILY INCREASING AMONG IMMUNOSUPPRESSED AND CANCER PATIENTS. FOR THIS REASON, THERE IS A NEED FOR AN EFFECTIVE, NON-TOXIC WATER SOLUBLE ANTIFUNGAL AGENT. THE OBJECTIVE OF THIS RESEARCH IS TO PREPARE AND CHARACTERIZE THE NOVEL ANTIFUNGAL ANTIBIOTIC HYDROHEPTIN, WHICH IS A MEMBER OF THE NON-AROMATIC HEPTAENE MACROLIDE GROUP AND IS REPORTED TO BE WATER SOLUBLE. THE SPECIFIC AIMS IN THE FIRST PHASE OF THE WORK WILL BE: 1) EVALUATION OF VARIOUS CULTURES AND CHARACTERIZATION OF THE BEST HYDROHEPTIN PRODUCERS, 2) DEVELOPMENT OF ANALYTICAL HPLC ASSAY METHOD FOR QUANTITATION, 3) DEVELOPMENT OF FERMENTATION CONDITIONS, 4) SCALE-UP OF THE FERMENTATION TO PILOT SCALE, 5) DEVELOPMENT OF AN EFFICIENT ISOLATION/PURIFICATION METHOD, AND 6) PREPARATION OF SUFFICIENT MATERIAL FOR BIOLOGICAL AND PHYSICOCHEMICAL STUDIES. STRAIN IMPROVEMENT, STRUCTURAL CHARACTERIZATION, CHEMICAL MODIFICATIONS AND EXTENDED ANTIFUNGAL ACTIVITY EVALUATION WILL BE PERFORMED IN THE SECOND PHASE OF DEVELOPMENT. INFORMATION, THAT IMPARTS WATER WOLUBILITY TO HYDROHEPTIN, MAY BE TRANSLATED INTO OTHER POLYENE MACROLIDES FOR IMPROVEMENT OF WATER SOLUBILITY AND ANTIFUNGAL ACTIVITY.

Principal Investigator:

Ramesh C Pandey
9082473300

Business Contact:

Small Business Information at Submission:

Xechm Inc
100 Jersey Ave New Brunswick, NJ 08901

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No