USA flag logo/image

An Official Website of the United States Government

Polarized Xenon Production Multi-liter Accumulation

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
71031
Program Year/Program:
2004 / STTR
Agency Tracking Number:
HL078285
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
XEMED, LLC
16 Strafford Avenue DURHAM, NH -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Polarized Xenon Production Multi-liter Accumulation
Agency: HHS
Contract: 1R41HL078285-01
Award Amount: $102,965.00
 

Abstract:

DESCRIPTION (provided by applicant): Since its first demonstration as an imaging agent in MRI nearly a decade ago, the promise of hyperpolarized xenon has captured the attention of the research community. It can be introduced into a subject non-invasively by breathing, and has a well-understood short-term biological effect. Relative to hyperpolarized helium, its advantages include its natural abundance and low cost. Both hyperpolarized xenon and helium have demonstrated utility in lung imaging, and quantifying lung disease. In contrast to helium, however, hyperpolarized xenon has a high solubility in fluids and tissues and a characteristic chemical shift, revealing its microscopic environment in dissolved-phase imaging. Consequently, the time dependence of its transport and absorption offer prospects for functional imaging of perfusion. Using NIH R21 and R15 funds, the UNH group demonstrated a new type of xenon polarizer that flows the gas mixture at relatively high velocity and low pressure along a direction opposite to the laser beam. This polarizer demonstrated polarization of over 20% for a production rate of over four liters per hour. The figure-of-merit (polarization times production rate) of this polarizer presently exceeds all other polarizer technologies by an order of magnitude. The technology routinely used to accumulate hyperpolarized xenon, freezing in a liquid-nitrogen bath, is not well suited to accumulating multi-liter quantities. We request STTR funding to develop and test a novel, scalable approach to accumulating unlimited quantities of hyperpolarized xenon. This new method of accumulating the hyperpolarized gas will extend the capacity of our world-leading hyperpolarized xenon production apparatus. This development helps to convert this laboratory installation to a practical hospital based device. Hyperpolarized gas has already demonstrated utility in diagnosing and quantifying lung disease. We present technological, physiological, and economic arguments that hyperpolarized xenon can and perhaps will surpass gadolinium as the contrast agent of choice in a broad spectrum of diagnostic imaging protocols.

Principal Investigator:

William Hersman
6038623512
hersman@unh.edu

Business Contact:

F. Hersman
6038623512
HERSMAN@UNH.EDU
Small Business Information at Submission:

XEMED, LLC
XEMED, LLC 9 LIBRARY WAY DURHAM, NH 03824

EIN/Tax ID: 201331118
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITY OF NEW HAMPSHIRE
OFFICE OF SPONSORED RESEARCH
Durham, NH 03824
RI Type: Nonprofit college or university