SBIR Phase I: Nuclear Magnetic Resonance Force Microscopy for Subcellular Imaging

Award Information

Agency: National Science Foundation

Branch: N/A

Contract: 0319874

Agency Tracking Number: 0319874

Amount: $100,000.00

Phase: Phase I

Program: SBIR

Solicitation Topic Code: N/A

Solicitation Number: N/A

Timeline

Solicitation Year: N/A

Award Year: 2003

Award Start Date (Proposal Award Date): N/A

Award End Date (Contract End Date): N/A

Small Business Information

XIDEX CORPORATION

8906 Wall Street, Suite 105

Austin, TX 78754

United States

DUNS: N/A

HUBZone Owned: No

Woman Owned: No

Socially and Economically Disadvantaged: No

Principal Investigator

Name: Vladimir Mancevski
Phone: () -

Business Contact

Phone: () -

Research Institution

N/A

Abstract

This Small Business Innovation Research (SBIR) Phase I project will demonstrate the feasibility of a nuclear magnetic resonance force microscope (NMRFM) that will make it possible for the first time ever to routinely image intracellular diffusion properties, relaxation times, and hydrogen densities of live cells with sub-optical spatial resolution, down to a volume resolution of 0.1 micron on a side. The hypothesis is that an NMRFM technique can be used for NMR-based imaging of living eucaryotic and procaryotic cells with sub-optical resolution, thereby allowing measurement of diffusion properties, relaxation times, and hydrogen (proton-spin) densities of the cell itself and its larger internal structures (e.g. nucleus, cytoplasm, plasma membrane, and mitochondria).

The commercial applications of this project will be in the research instrumentation market. Prospective customers include biologists, medical researchers, clinical practitioners, and others interested in functional and structural imaging of living cells and acellular tissue samples.

* Information listed above is at the time of submission. *

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SBIR Phase I: Nuclear Magnetic Resonance Force Microscopy for Subcellular Imaging