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Production of Y-90 Microspheres for Radiation Therapy

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
55572
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
2R44CA079225-02A1
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
XL SCI-TECH, INC.
3100 GEORGE WASHINGTON WAY RICHLAND, WA 99354-1663
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Production of Y-90 Microspheres for Radiation Therapy
Agency: HHS
Contract: N/A
Award Amount: $0.00
 

Abstract:

DESCRIPTION (Provided by Applicant): The feasibility of continuous and economical microfabrication of timed-bioresorbable glass microspheres containing yttrium-90 (Y-90) at therapeutic concentrations has been successfully demonstrated using Y-89 surrogate in the Phase I research. The microspheres are uniform in size and chemistry, and the timed-bioresorption characteristics can be predetermined according to the isotope half-life and the dosimetry requirements. A dependable commercial supply of Y-90 glass microspheres will have a positive impact on localized radiation therapy worldwide. This Phase II research has the objective of making such a supply a commercial reality. The proposed microfabrication process can be streamlined and fully automated from Y-90 isotope extraction to packaged Y-90 microspheres ready for delivery and treatment injection. The microsphere production process will be optimized with regard to minimized personnel radiation exposure, maximized use of source radioisotopes, much shortened overall process time to preserve radioactivity, and above all, much reduced cost. Microspheres containing therapeutic concentrations of radioisotopes will be evaluated in vitro for radioactivity retention, biocompatibility, and completeness of bioresorption; and in vivo to demonstrate the efficacy of the Y-90 microspheres in treating tumor-bearing rodents. PROPOSED COMMERCIAL APPLICATIONS: Timed-bioresorbable glass microspheres containing Y-90 are ideal for direct intratumoral injection in the treatment of cancers such as the liver, pancreas, or the synovectomy of rheumatoid arthritis. Microspheres containing other radioactive isotopes such as P-32 can also be readily produced by the methods described.

Principal Investigator:

Yongren B. Peng

Business Contact:


5096272049
CHERRYLEI@AOL.COM
Small Business Information at Submission:

XL SCI-TECH, INC.
BOX 1726, 3601 EQUESTRIAN DR WEST RICHLAND, WA 99352

EIN/Tax ID: 911709635
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No