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Nano Radioisotope Sources For Targeted Radiation Therapy

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
88851
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
CA124306
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
XL SCI-TECH, INC.
3100 GEORGE WASHINGTON WAY RICHLAND, WA 99354-1663
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: Nano Radioisotope Sources For Targeted Radiation Therapy
Agency: HHS
Contract: 1R43CA124306-01A1
Award Amount: $140,370.00
 

Abstract:

DESCRIPTION (provided by applicant): Radioisotopes used in targeted therapy are often labeled to targeting biomolecules. Different radioisotope and biomolecule usually require different linkage to bind the radioisotope to the targeting biomolecule. This pr oposed research is to create modular nano radioisotope sources for improving tumor targeting. Using fusion at the nano-scale, a class of new and low cost radioisotope sources can be created with the most desirable energy spectrum possible and can be modula rized and functionalized to revolutionize targeted delivery. Phase I of the proposed research will focus on the creation and functionalization of the nano-fused radioisotope sources. These nano radioisotopes are, potentially, ideal to be functionalized as a modular labeling block especially useful for targeted therapy. In vitro characterization of modularized and functionalized nano radioisotope sources will include radioactivity containment measurements in simulated body fluid. The labeling of such nano-fu sed radioisotope sources to selected biomolecules will be the focus of the Phase II research. PUBLIC HEALTH RELEVANCE: Tumor targeting is similar to a smart bomb aiming and destroying its target. The complication is to discover a working linkage to couple between a selected radioisotope (the bomb ) and a chosen targeting biomolecule. This project takes the first step in creating a plug-and-play tumor targeting system by modularizing radioisotope sources using fusion at the nano-scale such that linkages t o radioisotopes are simplified to ONE reliable and standard linkage.

Principal Investigator:

Yongren B. Peng
5093750884
BENPENG@XLSCITECH.COM

Business Contact:

Small Business Information at Submission:

XL SCI-TECH, INC.
3100 GEORGE WASHINGTON WAY RICHLAND, WA 99354

EIN/Tax ID: 911709635
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No