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Capillary Optics to Control Neutrons for BNCT

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
24835
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
24835
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
X-RAY OPTICAL SYSTEMS, INC.
15 Tech Valley Drive East Greenbush, NY 12061-4134
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Capillary Optics to Control Neutrons for BNCT
Agency: HHS
Contract: 1 R43 CA62702-1,
Award Amount: $73,739.00
 

Abstract:

Boron Neutron Capture Therapy is a two component modality. It is based on selective deliveryof a boronated pharmaceutical to cancerous tissue, followed by irradiation with thermal neutrons andsubsequently captured by the boron nuclei. A collaborative effort will be undertaken to develop aneutron gun capable of delivering a filtered, focused beam of thermal neutrons. This will provide a localtreatment modality which is extremely dose-sparing to healthy tissue. The neutron gun is based on theuse of a new technology, capillary neutron optics, which has recently demonstrated significant fluxenhancements for cold neutrons. Modeling based on experimental measurements of capillary optics willbe used to determine the feasibility of the device when paired with a variety of accelerator or reactorbased neutron sources. The project team includes experts in neutron optics, neutron sources, moderatordesign and modeling, and boron neutron capture therapy. The neutron gun will be of particular benefitfor intraoperative treatment of the surgical bed following gross total resection of tumors such as skin,breast, sarcoma and metastatic lesions, which typically require a local dose boost with conventionalradiation treatment. The neutron delivery system will also be advantageous for intraoperative treatmentafter exposure of ocular melanoma.

Principal Investigator:

Qi-Fan Xiao
5184425250

Business Contact:

Small Business Information at Submission:

X-ray Optical Systems, Inc.
9 Physics 1400 Washington Avenue Albany, NY 12222

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No