The Department of Energy is responsible for cleaning up and then conducting ongoing surveillance and maintenance of 113 contaminated sites across the nation. The long-term cost associated with surveillance and maintenance of these sites is estimated to be approximately $100 million per year for… More

The U.S. Air Force deploys and encounters a highly diverse spectrum of chemicals and materials. The health hazards of these materials must beevaluated to protect personnel and to minimize life cycle costs for weaponsystems. To evaluate health risks, chemical toxicity information is needed.However… More

65525 The Department of Energy is responsible for cleaning up and then conducting ongoing surveillance and maintenance of 114 contaminated sites across the nation. The long-term cost associated with surveillance and maintenance of these sites is estimated to be approximately $100 million per… More

This Small Business Technology Transfer (STTR) Phase I project will address the problem of creating robust and efficient software for the solution of large-scale nonlinear optimization problems. Taking advantage of recent advances in algorithm design, the project will investigate novel versions of… More

DESCRIPTION (provided by applicant): YAHSGS' Toxicological Evaluation Neuralnet Tools (TEND is designed to advance the state-of-the-art in the prediction of toxicological end points for new or untested chemicals, drugs, and compounds. TENT deploys computational neural nets (CNN), innovative… More

75180-Researchers in the Genomes to Life program, as well as in other biomedical research programs, need a more effective way to search across the multiple heterogeneous databases that are compiling information approaching petabyte levels. Current approaches are limited because they are based on… More

DESCRIPTION (provided by applicant): This project bridges the understanding between physical and chemical principles and genomic/proteomic response by integrating three independent parallel toxicity prediction tools. Each uses computational neural networks (CNNs) and wavelets to rapidly and… More

DESCRIPTION (provided by applicant): User-friendly, intelligent, computer-based data mining tools are critical to fully realizing biomedical and toxicology researchers' effectiveness in uncovering knowledge contained in biomedical and toxicology databases and maximizing cross-scientific benefits.… More

DESCRIPTION (provided by applicant): The high cost ($0.8 - $1.7 billion) and long time frames (about 13 years) required to introduce new drugs to the market contributes substantially to spiraling health care costs and diseases persisting without effective cures. A major factor is the high attrition… More

The goal of this project is to create bioinformatics software that will rapidly and accurately search and mine proteomics-related information from multiple databases and relate the expression of proteins to upstream or downstream events. The proposed product will link upstream and downstream data to… More

DESCRIPTION (provided by applicant): The goal of this Phase I project is to demonstrate the feasibility of advancing prototype software (successfully tested on hepatotoxicity) to (1) achieve accurate toxicological endpoint predictions for multiple human or gans, and (2) automate processes thereby… More