OVERCOMING NUTRIENT MALABSORPTION IN CYSTIC FIBROSIS
DESCRIPTION: In cystic fibrosis (CF), pancreatic insufficiency and a diminished
bile acid pool cause malabsorption of vitamin E, carotenoids and other
fat-soluble antioxidants, which contributes to resulting oxidative stress and
poor nutritional status, both of which are associated with increased risk of
disease, neurological dysfunction and reduced quality of life. The object of
this study is to determine the feasibility of using an oral liquid formulation
of micellar-like vehicles to overcome malabsorption of important nutrients and
antioxidants and therefore improve oxidation and nutrition status. The
researchers intend to study a unique generally regarded as safe (GRAS) molecule
as the delivery vehicle for fat-soluble nutrients and antioxidants. The
formulation will be optimized for physical and chemical stability, and for
taste acceptable to children and young adults. Although tested first in cystic
fibrosis patients, this technology could be useful to other fat malabsorbers.
The technology is based on d-alpha-tocopheryl polyethylene glycol 1000
succinate or TPGS.
PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
Small Business Information at Submission:
Principal Investigator:Michael G. Nicolaou
YASOO HEALTH, INC.
SAN DIEGO TECHNOLOGY INCUBATOR 1425 RUSS BLVD, STE T-107 SAN DIEGO, CA 92101
Number of Employees: