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Commercialization of Human Visceral Adipocytes

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66376
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
DK065323
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ZEN-BIO, INC.
P.O. BOX 13888 3200 CHAPEL HILL-NELSON BLVD. RTP, NC 27709-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2005
Title: Commercialization of Human Visceral Adipocytes
Agency: HHS
Contract: 2R44DK065323-02A1
Award Amount: $961,578.00
 

Abstract:

DESCRIPTION (provided by applicant): The US is experiencing an epidemic rise in obesity and related co-morbidities such as type II diabetes. Epidemiological studies demonstrate that these co-morbidities are specifically correlated with visceral (intra-abdominal) fat deposition. To elucidate this association, a fully characterized and performance tested cultured human adipocyte cell system must be made available to researchers. The goal of the proposed work is to develop a commercially accessible, novel, well characterized cultured human visceral adipocyte cell system. Preliminary data indicate visceral adipocytes are distinct from subcutaneous adipocytes, requiring individualized culturing and assaying techniques. Phase II has three specific aims. I. Establish a protocol for differentiation of visceral preadipocytes into adipocytes. II. Develop a suite of assays necessary to provide quality control tests for the cultured cells. The assays will also be offered as a commercial contract research service utilizing the visceral cell system. III. Perform expression profiling of primary and cultured visceral adipocytes and preadipocytes in order to validate the cultured cell system. The completion of the research will result in a commercially accessible, performance tested, fully validated cultured human visceral adipocyte cell system. Availability of this system will open the door for large scale screening in cultured human visceral cells, provide a better understanding of the roles visceral adipose plays in disease development and provide a faster and less expensive path to drug development.

Principal Investigator:

Yolanda R. Leacurrie
9195470692
RENEE@ZEN-BIO.COM

Business Contact:

Peter Pieraccini
9195470692
PETER@ZEN-BIO.COM
Small Business Information at Submission:

Zen-Bio, Inc.
P.O. Box 13888 3200 Chapel Hill-Nelson Blvd. Rtp, NC 27709

EIN/Tax ID: 561940166
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No