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Surface Carbon Clad Zirconia as Chiral Stationary Phases

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
54107
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43HL070334-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Zirchrom Separations, Inc.
Zirchrom Separations, Inc. 617 Pierce St Anoka, MN 55303-0160
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Surface Carbon Clad Zirconia as Chiral Stationary Phases
Agency: HHS
Contract: N/A
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): We propose to research and develop means to reproducibly and economically synthesize and use a new class of chiral stationary phases (CSPs) under normal phase conditions based on carbon surfaces. The main goal of this work will be the development a commercially viable reproducible method of synthesizing 3 micron' porous carbon clad-zirconia microsphere derivatized With two Pirkle-typme ligands,namely -(S, S) Whelk-D 1 and about-Burke 1. The key novel approach that we will take is the use of a nonpolar surface, as, the substrate for attaching chiral selectors. This approach to the production of a chiral stationar phase has not been previousl explored and be1ieve that it offers significant advantages over current material's. Once these phases have been developed they will be used to demonstrate'the feasibility of separating several classes of chiral pharmaceuticals including f3-blockers. They will compare separation performance with current state of the art (Pirkie-type) CSPs coupled to silica. We will also test the feasibility of doing chiral separations of basic chiral pharmaceuticals without the presence of special eluent additives, which are currently required. This project will be conducted in close collaboration with Professor Tom Hoye at the University of Minnesota, and Dr. Angelos Kyrlidis at cabot Corporation. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

Principal Investigator:

Clayton V. Mcneff

Business Contact:


6124215264
WWW.ZIRCHROM.COM
Small Business Information at Submission:

ZIRCHROM SEPARATIONS, INC.
617 PIERCE ST ANOKA, MN 55303

EIN/Tax ID: 411821147
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No