DESCRIPTION (provided by applicant): Starting materials based on rare sugars that are used in the production of carbohydrate-based drugs are in low supply, therefore creating high prices. One such carbohydrate is L-ribose. L-Ribose is used in many different applications, including several… More

DESCRIPTION (provided by applicant): Natural product glycosylation is vital for the discovery of new pharmaceutical compounds. While it has been recognized for some time that many biologically active natural products owe much of their therapeutic properties to their glycosylation diversity, methods… More

DESCRIPTION (provided by applicant): Carbohydrates play an important role in many cellular functions and diseases; however, carbohydrate-based drug discovery research is lagging compared to other biologically important molecules because of the significant challenges in creating and obtaining… More

DESCRIPTION (provided by applicant): This Phase I proposal is to develop glycopeptide neoglycosides against VanA-resistant and VanB-resistant organisms. The clinical relevance of such compounds stems from the sharp rise in VRE (vancomycin-resistant enterococci, and more recently staphylococci)… More

In the production of ethanol from corn, the current process utilizes only the starch. Left unused is a significant amount of by-products, which also are produced during ethanol production. If these byproducts, which are rich in pentose and other sugars, could be made into a valuable product, the… More

When ethanol is produced from corn, only the starch is transformed, and a significant amount of byproducts is produced. If these byproducts, which are rich in sugars, could be made into a valuable product, the cost-effectiveness of ethanol production will be enhanced. One such potential product is… More

This Small Business Innovation Research (SBIR) Phase I project focuses on the production of xylitol from glycerol, a byproduct of biodiesel production. By converting crude glycerol to a value-added coproduct there will be significant improvement in biodiesel production economics. Xylitol has health… More

DESCRIPTION (provided by applicant): The overall goal of this proposal is to create a robust one pot, in vitro, multi-gram scale synthesis of activated sugars for drug discovery and biochemical research purposes. Natural product glycosylation is vital for the discovery of new pharmaceutical… More

This SBIR Phase II project will develop a method to convert the byproduct glycerol to a value-added co-product, xylitol, thereby helping to reduce the costs associated with biodiesel production. The anticipated result is a scalable process capable of converting crude glycerol to xylitol in a single… More

DESCRIPTION (provided by applicant): The ultimate goal of the proposal presented herein is to use E. coli as whole cell biocatalysts for the production of a wide variety of TDP-deoxysugars including di- and tri-deoxysugars, amino sugars and branched-chainsugars. These specialized activated hexoses… More