USA flag logo/image

An Official Website of the United States Government

Z-Tag for Measuring Cardiac Contractility and Cardiac Rhythmicity

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
85828
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
HL088809
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ZYGOGEN, LLC
58 Edgewood Avenue 1st Floor, Room 122 ATLANTA, GA 30303
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: Z-Tag for Measuring Cardiac Contractility and Cardiac Rhythmicity
Agency: HHS
Contract: 1R43HL088809-01
Award Amount: $153,994.00
 

Abstract:

DESCRIPTION (provided by applicant): A major concern regarding drugs in development is cardiac toxicity. Commonly, drugs in development can cause changes to cardiac contractility, the force with which the heart beats, and cardiac rhythmicity, resulting in toxic side effects. The purpose of this Phase 1 proposal is to develop zebrafish assays for measuring drug-induced changes in cardiac contractility and cardiac rhythmicity. These assays will be developed using a transgenic zebrafish line expressing a green fluorescent reporter protein specifically in the heart. Methods of assessing contractility and rhythmicity in zebrafish will be developed. Drugs that are known to cause changes to cardiac contractility and rhythmicity in humans will be tested using these zebrafish in order to validate the assay. Development of these assays will allow high-throughput, in vivo testing of drugs in development for cardiac toxicity.

Principal Investigator:

Peter M. Eimon
4045237309
PETER@ZYGOGEN.COM

Business Contact:

Nina Sawcxuk
nina@zygogen.com
Small Business Information at Submission:

ZYGOGEN, LLC
58 Edgewood Avenue 1st Floor, Room 122 ATLANTA, GA 30303

EIN/Tax ID: 582484200
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No