THERMOPLASTIC POLYURETHANE WITH ENHANCED BIOSTABILITY
DESCRIPTION (Verbatim From Applicant's Abstract): Our novel and innovative
approach for improving the biostability of thermoplastic polyurethane Consists
of chemically modifying tpu and crosslinking it with electron beam radiation.
The objective of this Phase I proposal is to evaluate, using a combination of
in vivo and in vitro studies, the degree to which this innovative approach
improves the biostability of TPU.
An improvement in the blostability of TPU would have wide application in
biomedical devices especially in Cardiac Pacemakers.
Cardiac pacemakers are medical devices, which regulate cardiac rhythmic
disorders. Pacemakers comprise a generator, connected to an insulated lead,
which is implanted in the heart. Electrical pulses transmitted via the lead are
timed to stimulate the heart muscle in a regulated manner. Pacemaker failures
may result from deterioration of the pacemaker lead wire insulation. A tailed
lead must be surgically replaced. The availability of a cardiac pacemaker wire
insulation with increased implant lifetime would be of great value to the
medical profession, Such improved leads would eliminate or greatly reduce the
requirement for costly and risky surgical lead replacement procedures.
A successful demonstration of increased biostability of cross-linked tpu would
encourage commercialization of pacemakers utilizing crosslinked tpu insulated
PROPOSED COMMERCIAL APPLICATION:
Potential commercial applications include pacemaker leads, Vascular grafts, Artifical hearts,
Neurological leads, Arterio-venous dialysis shunts, Implantable defibrillators, Wound dressings,
Cardiac catheter, Urethral catheters Mammary prostheses, IV bags and tubing, Chemotherapy
tubing, Joint protheses, Cardiac valves, and cardiac assist devices such as aortic balloon
Small Business Information at Submission:
Principal Investigator:Alan M. Zamore
600 D RTE 45 CHESTNUT RIDGE, NY 10977
Number of Employees: