Methods are being investigated to increase the efficacy of producing monoclonal antibodies to trace quantities of peptides and proteins that are of high value to science and industry. the research will lead to the development of diagnostic and therapeutic antibodies having characteristics superior… More

The goal of this project is to create a stable murine myeloma cell line that secretes a human antibody against anthrax exotoxin. the molecular cloning of human immnuoglobulin (ig) genes from the genomic dna of a human/ mouse hybridoma is proposed. the human ig genes, which encode an antibody against… More

The goal of the project is the development of a commercially feasible system for the production of human granulocyte-macrophage colony stimulating factor (gmcsf) for use as a therapeutic agent in the treatment of patients whose immune system has been suppressed as a result of treatment with… More

A full-length coding sequence for human protein c will be cloned. this will be done either by obtaining a 5' end clone from a liver cdna library or by fusing a genomic dna sequence to cdna, which lacks an aminoterminal coding sequence. once this clone is complete is will be introducedinto an… More

The goal of this project is to develop a commercially feasible system for the production of the human equivalent of interleukin-3 (il-3) for use as a therapeutic agent in the treatment of patients whose hematopoiesis has been suppressed as a result of chemotherapy or radiation therapy,or who are… More

Bile salt-activated lipase (bsal) is found in the milk of a limited number of mammals: humans, gorillas, dogs, and cats the enzyme plays an important role in the infant diet in thedigestion of lipids, causing a striking quantitative dif- ference between breast-fed and formula-fed infants in… More