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EXOTOXIN

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4704
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1986
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
2121 North 35th Street
Seattle, WA 98103
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 WAYNE KINDSVOGEL
 PRINCIPAL INVESTIGATOR
 (206) 632-4036
Business Contact
Phone: () -
Research Institution
N/A
Abstract

THE GOAL OF THIS PROJECT IS TO CREATE A STABLE MURINE MYELOMA CELL LINE THAT SECRETES A HUMAN ANTIBODY AGAINST ANTHRAX EXOTOXIN. THE MOLECULAR CLONING OF HUMAN IMMNUOGLOBULIN (IG) GENES FROM THE GENOMIC DNA OF A HUMAN/ MOUSE HYBRIDOMA IS PROPOSED. THE HUMAN IG GENES, WHICH ENCODE AN ANTIBODY AGAINST ANTHRAX EXOTOXIN, WILL BE SPLICEDTO PREVIOUSLY CHARACTERIZED MOUSE IG GENES. THE RESULTING CHIMERIC IG GENES CONTAINING MURINE TRANSCRIPTIONAL SIGNALS AND HUMAN IG CODING REGIONS WILL BE TRANSFECTED INTO A NON- PRODUCING MURINE MYELOMA CELL LINE. THE TRANSFECTED CELLS WILL THEN BE SCREENED FOR THOSE CELLS THAT PRODUCE HUMAN ANTIBODIES AGAINST ANTHRAX EXOTOXIN. CHARACTERIZATION AND SCALE UP OF THE CELL LINE CREATED IN PHASE I AS WELL AS THE ANTIANTHRAX ANTIBODY IT PRODUCES WILL RESULT IN A VALUABLE PRODUCT. FURTHERMORE, THE DATA OBTAINED SHOULD APPLY TO SUCCEEDING CELL LINES CREATED BY TRANSFECTING DIFFERENT IG GENES INTO THE SAME MURINE MYELOMA RECIPIENT. THIS TECHNOLOGY ALLOWS ONE TO EXPRESS AN ENDLESS SERIES OF DIFFERENT HUMAN ANTIBODIES IN THE SAME MURINE MYELOMA CELL LINE. FURTHERMORE, IT ALLOWS ONE TO PRODUCE NOVEL ANTIBODIES SUCH AS CHIMERIC MOUSE/HUMAN ANTIBODIES IN THE SAME MURINE MYELOMA CELL LINE.

* Information listed above is at the time of submission. *

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