DESCRIPTION (provided by applicant): The goal of this project is to develop unique column packings for high-performance liquid chromatography. These new materials will allow the very fast separation and characterization of both small molecules of biological and pharmaceutical interest and very large… More
Award Year / Program / Phase:2008 / SBIR / Phase II
Agency:HHS
Principal Investigator:
Award Amount:$675,000.00
Abstract:
DESCRIPTION (provided by applicant): This project proposes unique column packings for the fast high-performance HPLC of biomacromolecules. Initial focus will be on developing techniques to modify the chemistry of silica surfaces using hydrothermal methods,
so that biomolecular separations are… More
DESCRIPTION (provided by applicant): Analysis of glycoprotein polypeptide sites of carbohydrate attachment and the structures of the glycans present on these proteins requires the combination of high resolution chromatographic separations and sophisticatedmass spectrometry. Hydrophilic interaction… More
DESCRIPTION (provided by applicant): Life sciences research and other critical bioanalytical applications would strongly benefit from faster and higher resolution liquid chromatographic (HPLC) separations for both small molecules and larger molecules suchas proteins, peptides, glycopeptides, and… More