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Rational Design of Antibiotics Targeted at the Ribosome

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60497
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
AI051104
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANADYS PHARMACEUTICALS, INC.
3115 MERRYFIELD ROW SAN DIEGO, CA 92121
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2004
Title: Rational Design of Antibiotics Targeted at the Ribosome
Agency: HHS
Contract: 2R44AI051104-02A1
Award Amount: $1,205,000.00
 

Abstract:

DESCRIPTION (provided by applicant): Rapid and widespread emergence of antibiotics-resistant pathogens creates an urgent need for concerted approaches towards novel antiinfectives. The long-term objective of this proposal is the development of novel potent antibacterials that target the ribosomal RNA (rRNA) of antibiotics-resistant bacteria. Specifically, a lead series of small molecules that recognize the ribosomal decoding-site RNA (A-site) will be developed to select an antibacterial drug candidate by iterative rounds of synthesis and testing for target binding, inhibition of protein synthesis and bacterial growth. The ribosomal A-site constitutes a prime target for antibiotics, validated by the naturally occurring aminoglycosides and a novel series of chemically unrelated antibacterials that we have discovered recently. Rational structure-based design along with multi-dimensional drug optimization, using testing data from a range of biochemical and biological assays, will allow us to develop a novel class of antibiotics that are not susceptible to known bacterial resistance mechanisms. These novel antibacterial A-site ligands will constitute the first class of antibiotics that has been developed by a rational approach of drug discovery specifically directed at an RNA component of the bacterial ribosome.

Principal Investigator:

Thomas C. Hermann
8585303659
THERMANN@ANADYSPHARMA.COM

Business Contact:

Kleanthis Xanthopoulos
8585303600
KGX@ANADYSPHARMA.COM
Small Business Information at Submission:

ANADYS PHARMACEUTICALS, INC.
3115 MERRYFIELD ROW SAN DIEGO, CA 92121

EIN/Tax ID: 223193172
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No