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Biomaterials for Adhesion-Free Tendon Repair

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
75963
Program Year/Program:
2005 / STTR
Agency Tracking Number:
AR052562
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
RECOGNITION ROBOTICS, INC.
4650 East Lake Rd. Sheffield Lake, OH 44054
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Biomaterials for Adhesion-Free Tendon Repair
Agency: HHS
Contract: 1R41AR052562-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): The formation of adhesions following flexor tendon surgery in the hand is a common post-operative complication. Adhesions can severely impair the function and range of motion of the affected digit and can cause the partial loss of hand function. Injection of hyaluronan (HA) or insertion of barriers prepared from chemically-modified HA are currently used to reduce adhesions, but the short half-lives of injected HA or HA barriers compromises their efficacy in preventing adhesions. To address this problem, we recently developed a novel in situ crosslinkable HA hydrogel that can contain the antiproliferative drug mitomycin C (MMC) via a covalent linkage. In preliminary results, film barriers and injectable forms of this HA-MMC hydrogel prevented the formation of intraperitoneal adhesions in a rat uterine horn model. We now propose to establish the feasibility of using this material to address the important unmet surgical need in tendon surgery. The ultimate goal of this program is to demonstrate that post-operative tendon adhesions can be reduced or eliminated by a composite material that promotes the healing of the surgically repaired tendon while simultaneously preventing adhesion formation to surrounding tissues. This goal will be addressed experimentally through four specific aims. First, we will prepare crosslinked gels with different MMC concentrations and determine the rate of MMC release from the films. Second, we will determine the biocompatibility in vivo by subcutaneous injection of the in situ crosslinkable gels in rodents. Third, we will fabricate films and tubes using the HA-MMC materials. Finally, we will determine the efficacy of these HA-MMC devices in a rabbit digital flexor tendon model using functional, biomechanical, and histological criteria.

Principal Investigator:

Glenn D. Prestwich
8015859051
GPRESTWICH@PHARM.UTAH.EDU

Business Contact:


8012323603
Small Business Information at Submission:

Sentrx Surgical, Inc.
675 Arapeen Drive, Suite 302 Salt Lake City, UT 84108

EIN/Tax ID: 200915291
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
THE UNIVERSITY OF UATH
75 South 2000 East
Room 111
SALT LAKE CITY, UT 84112
RI Type: Nonprofit college or university