Malaria is a major health problem worldwide, and its significance may be on the increase due to the rapid spread of parasite strains that are resistant to conventional anti-malaria drugs. Evidence suggests that during the inital phase of infection(liver-stage) the Plasmodium parasites may be… More

This Small Business Innovation Research Phase I project aims to develop a technology that employs polyclonal antibodies as a complex probe to discover tumor associated surface antigens, a process named Dual Immunostaining-mediated Subtractive Cloning(DISC). Antibodies have been the most powerful… More

The discovery and identification of novel tumor associated antigens (TAAs) is critical for the advancement of accurate cancer diagnosis and staging. This Small Business Innovation Research Phase II project aims to continue development and application of anovel technology, Dual Immunostaining… More

This SBIR Phase I project will lead to the development of a technology to detect very low levels of multiple pathogen-specific proteins or human proteins very quickly after exposure to biological warfare (BW) agents. The technology will link several proven techniques in a unique sequence so that a… More

DESCRIPTION (provided by applicant): The objective of this proposal is to develop a novel technology for detecting multiple protein markers for disease management. In this project, the technology will be used in profiling the phosphorylation state of numerous proteins in a single test. Most… More

DESCRIPTION (provided by applicant): In order to understand the pathogenesis of cancer, it will be critical to elucidate the cellular signaling pathways that contribute to oncogenic transformation. Complex networks of protein kinases and adaptor proteins play a central role. These molecules undergo… More