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Aptamers for Ante-mortem Diagnostics of Prion Infection

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
85069
Program Year/Program:
2008 / STTR
Agency Tracking Number:
A08A-035-0122
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Infoscitex Corporation
303 Bear Hill Road Waltham, MA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: Aptamers for Ante-mortem Diagnostics of Prion Infection
Agency / Branch: DOD / ARMY
Contract: W81XWH-08-C-0104
Award Amount: $99,995.00
 

Abstract:

All forms of transmissible spongiform encephalopathy (TSE) are caused by a unique infectious agent termed "prion", a proteinaceous pathogen lacking nucleic acid. Prions are actually a misfolded variant of the normal mammalian prion protein, PrPc. Normal disease transmission occurs when prions are ingested by a naive animal. The current test for TSE is a post mortem diagnosis looking for protease-resistant PrPSc in brain tissue by immunohistochemistry. The ante mortem diagnosis of prion disease is complicated due to very low concentration of PrPsc and high presence of PrPc associated with all blood components and serum even in infectious animals. Any blood diagnostic test would need to discriminate pg/mL concentrations of PrPsc from PrPc. To address the need for ante mortem diagnosis of the prion disease the IST and CSU team will attempt detection of the pg quantities of PrPsc /mL directly in bodily fluids using uniquely specific and highly affinitive DNA aptamers developed using our proprietary technology for DNA aptamer production.

Principal Investigator:

Vladimir Gilman
Senior Engineer
7818901338
vgilman@infoscitex.com

Business Contact:

William F. Thompson
Contracts Manager
7818901338
bthompson@infoscitex.com
Small Business Information at Submission:

INFOSCITEX CORP.
303 Bear Hill Road Waltham, MA 02451

EIN/Tax ID: 043537120
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
COLORADO STATE UNIV.
408 Univ Services Center
Fort Collins, CO 80523-2002
Contact: Chris Getzelman
Contact Phone: (970) 491-0439
RI Type: Nonprofit college or university