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IT IS THE OVERALL OBJECTIVE OF THIS PROJECT TO DEVELOP A TELEOST FRY EXPLANT…
- Small Business Information
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Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 1
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Fiscal Year: 1984Title: IT IS THE OVERALL OBJECTIVE OF THIS PROJECT TO DEVELOP A TELEOST FRY EXPLANT PROCEDURE AS A SIMPLE, SENSITIVE, RAPID METHOD OF EVALUATING AQUATIC POLLUTANTS.Agency: HHSContract: N/AAward Amount: $50,000.00
Abstract:
IT IS THE OVERALL OBJECTIVE OF THIS PROJECT TO DEVELOP A TELEOST FRY EXPLANT PROCEDURE AS A SIMPLE, SENSITIVE, RAPID METHOD OF EVALUATING AQUATIC POLLUTANTS. PHASE I WILL DETERMINE THE FEASIBILITY OF SUCH A SYSTEM BY EVALUATING THE TECHNIQUE WITH A DIRECT ACTING PROCARCINOGEN (BENZIDINE HYDROCHLORIDE) AND A MUTAGEN (MITOMYCIN C.) PHASE I EXPERIMENTS WILL UTILIZE TWO TELEOST SYSTEMS -- THE SHEEPHEAD MINNOW (CYPRINODON VARIEGATUS) AND THE RAINBOW TROUT (SALMO GAIRDNERI). EXPOSED EXPLANTS WILL BE EXAMINED MORPHOLOGICALLY, CYTOGENETICALLY (I.E. CHROMOSOME BANDING, SISTER-CHROMATID EXCHANGE) AND EVALUATED FOR THEIR ABILITY TO FORM COLONIES. IN ADDITION, THE MIXED FUNCTION OXIDIZED SYSTEM OF THE EXPLANTS WILL BE EVALUATED. IN PHASE II, IT IS OUR INTENT TO PRODUCE MONOCLONAL ANTIBODIES RECOGNIZED ALL SURFACE ANTIGENS OF TRANSFERRED CELLS, AND TO USE THESE ANTIBODIES AS REAGENTS AS EARLY INDICATIONS OF CELL TRANSFORMATIONS IN THE TELEOST EXPLANT SYSTEM.Small Business Information at Submission:Principal Investigator:
Paula gregory
0Business Contact:
Innovative Technology Inc.
Southern Station P.o. Box 10072 Hattieburg, MS 39406EIN/Tax ID:DUNS: N/ANumber of Employees: N/AWoman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
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Agency: Department of Health and Human Services |
Branch: N/A |
Award ID: 1442 |
Program Year/Program: 1984 / SBIR |
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Agency Tracking Number: 1442 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |