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IT IS THE OVERALL OBJECTIVE OF THIS PROJECT TO DEVELOP A TELEOST FRY EXPLANT…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
1442
Program Year/Program:
1984 / SBIR
Agency Tracking Number:
1442
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Innovative Technology Inc
Box 10072 - Southern Sta Hattiesburg, MS 39406
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1984
Title: IT IS THE OVERALL OBJECTIVE OF THIS PROJECT TO DEVELOP A TELEOST FRY EXPLANT PROCEDURE AS A SIMPLE, SENSITIVE, RAPID METHOD OF EVALUATING AQUATIC POLLUTANTS.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

IT IS THE OVERALL OBJECTIVE OF THIS PROJECT TO DEVELOP A TELEOST FRY EXPLANT PROCEDURE AS A SIMPLE, SENSITIVE, RAPID METHOD OF EVALUATING AQUATIC POLLUTANTS. PHASE I WILL DETERMINE THE FEASIBILITY OF SUCH A SYSTEM BY EVALUATING THE TECHNIQUE WITH A DIRECT ACTING PROCARCINOGEN (BENZIDINE HYDROCHLORIDE) AND A MUTAGEN (MITOMYCIN C.) PHASE I EXPERIMENTS WILL UTILIZE TWO TELEOST SYSTEMS -- THE SHEEPHEAD MINNOW (CYPRINODON VARIEGATUS) AND THE RAINBOW TROUT (SALMO GAIRDNERI). EXPOSED EXPLANTS WILL BE EXAMINED MORPHOLOGICALLY, CYTOGENETICALLY (I.E. CHROMOSOME BANDING, SISTER-CHROMATID EXCHANGE) AND EVALUATED FOR THEIR ABILITY TO FORM COLONIES. IN ADDITION, THE MIXED FUNCTION OXIDIZED SYSTEM OF THE EXPLANTS WILL BE EVALUATED. IN PHASE II, IT IS OUR INTENT TO PRODUCE MONOCLONAL ANTIBODIES RECOGNIZED ALL SURFACE ANTIGENS OF TRANSFERRED CELLS, AND TO USE THESE ANTIBODIES AS REAGENTS AS EARLY INDICATIONS OF CELL TRANSFORMATIONS IN THE TELEOST EXPLANT SYSTEM.

Principal Investigator:

Paula gregory
0

Business Contact:

Small Business Information at Submission:

Innovative Technology Inc.
Southern Station P.o. Box 10072 Hattieburg, MS 39406

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No