USA flag logo/image

An Official Website of the United States Government

Scaling up bacterial minicell production

Award Information

Agency:
Department of Health and Human Services 		Branch:
N/A 		Award ID:
89198 		Program Year/Program:
2008 / SBIR
Agency Tracking Number:
GM084517 		Solicitation Year:
N/A 		Solicitation Topic Code:
N/A 		Solicitation Number:
N/A
Small Business Information
VAXIION THERAPEUTICS, INC.
VAXIION THERAPEUTICS, INC. 6335 FERRIS SQ, STE A SAN DIEGO, CA 92121-3249
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: Scaling up bacterial minicell production
Agency: HHS
Contract: 1R43GM084517-01
Award Amount: $130,000.00
 

Abstract:

DESCRIPTION (provided by applicant): Scaling up bacterial minicell production This project is focused around scaling up bacterial minicell production to meet projected market demands of any of Vaxiion minicell-based products. We propose to construct a pa nel of minicell producing strains from E. coli, Salmonella spp, Shigella spp, and Campylobacter using a single genetic approach that has been optimized to maximize minicell productions across the panel. The first aim of this proposal is to identify exactly which genes within the highly conserved ftsQAZ need to be over expressed to obtain maximum minicell production. The second aim of this proposal is to introduce, using the same procedure and materials in parallel, the gene combination identified in the pre vious effort on to the chromosome of each of the organisms listed. These strains will then be tested for production capacity in growth conditions optimized in small scale (lt10L) fermentation runs on an experimental basis in conjunction with a CMO that wil l eventually be handling all future large scale (lt100L) production. PUBLIC HEALTH RELEVANCE: Scaling up bacterial minicell production Vaxiion Therapeutics, Inc. Is focused on brining several proprietary bacterial minicell-based products to market. Witho ut going into much detail here, Vaxiion has positioned the bacterial minicell platform technology to be used in vaccine development, targeted delivery of cancer therapeutics, and early stage in vivo targeted tumor bio-imaging. While all three programs are making progress in their respective stages of preclinical development, there remains one vital issue that all of these would be products have in common that must be addressed if minicells are ever to be brought to market. The issue is the ability of Vaxiio n to scale up both production and purification to meet projected demand for all of these products. The funds, if awarded for this Phase I SBIR grant proposal will be used to address production, while Phase II would focus primarily on large scale production and purification.

Principal Investigator:

Business Contact:

Small Business Information at Submission:

VAXIION THERAPEUTICS, INC.
VAXIION THERAPEUTICS, INC. 6335 FERRIS SQ, STE A SAN DIEGO, CA 92121

EIN/Tax ID: 133097288
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No