Microwave Treatment of Localized Prostate Cancer
DESCRIPTION (Provided by the Applicant): The specific aims of the proposed
Phase II program are to design, fabricate, and test in the prostates of dogs an
improved instrument for hyperthermia treatments of localized prostate cancer.
The instrument will use two cooperating transrectal and transurethral microwave
balloon catheters to safely and uniformly heat diseased prostates to optimum
therapeutic temperatures. Treatment temperatures will be monitored by means of
therrnocouples and a digital microwave radiometer. The proposed hyperthermia
instrument will conform to all applicable clinical safety standards and will be
ready for clinical trials in a follow-on program. The instrument will be
self-contained. Prostate temperatures will be optimized by a microprocessor
that automatically determines the appropriate amount of microwave power to be
broadcast by each microwave balloon catheter.
The addition of hyperthermia produced by microwave balloon catheters to
radiation therapy [external beam or implant therapy1 can be expected to result
in improved local control and overall survival rates in patients with localized
prostate cancer. Dual microwave balloon hyperthermia would improve the quality
of life of those patients that have constricted urethras by producing
biological stents in their urethras, and should also prove useful as a
stand-alone therapy for palliative treatments of patient with local recurrences
after radiation therapy.
PROPOSED COMMERCIAL APPLICATION:
Prostatic cancer affects many men and the overall treatment costs are extremely high.
The proposed approach has the potential for providing and adjuvant treatment that may
be performed on an "out-patient" basis to improve the survival rates in patients being
treated with external beam or implant therapy radiation. The new type of catheters
developed during the proposed program and the associated hyperthermia equipment will
be important commercial products.
Small Business Information at Submission:
Principal Investigator:Fred Sterzer
12 ROSZEL RD, STE A-203 PRINCETON, NJ 08540
Number of Employees: