USA flag logo/image

An Official Website of the United States Government

Company Information:

Name: MOLECULAR EXPRESS, INC.
Address: 1111 N HYLAND AVE
AMES, IA 50014-
Located in HUBZone: No
Woman-Owned: Yes
Minority-Owned: No
URL: N/A
Phone: (515) 292-5141

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $959,520.00 5
STTR Phase I $206,257.00 2
STTR Phase II $1,349,935.00 1

Award List:

Targeted Aptamer Probes for Nucleic Acid Detection

Award Year / Program / Phase: 2001 / STTR / Phase I
Agency: HHS
Research Institution: IOWA STATE UNIVERSITY
Principal Investigator: Richard T. Hamilton
Award Amount: $106,257.00
RI Contact: N/A
Abstract:
The eventual goal of the current research is to develop probes for in vivo imaging of gene expression and for in vivo targeting of cells for killing or remediation. The current proposal describes a novel nucleic acid probe design that will provide the basis of the new technology required for these… More

Aptamer-Based Analysis and Extraction of Sitosterol and Related Compounds

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: DOE
Principal Investigator: Richard Hamilton
Award Amount: $100,000.00
Abstract:
70846 Oilseed contains sterols and related compounds with economic potential. The extraction and analysis of these compounds would be aided by the availability of highly selective aptamers with high affinities for their particular sterol ligands. This project will develop aptamers for use in… More

N/A

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard Hamilton
Award Amount: $100,000.00

Anti-PSCA allosteric CLAMPs

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard T. Hamilton
Award Amount: $395,019.00
Abstract:
DESCRIPTION (provided by applicant): We propose to develop a novel cancer therapy using allosteric reagents for concentrating a prodrug around a target cancer cell. Our aptamer-based design, called a CLAMP (cis-linked aptamers for medical or microanalytical procedures), is a nucleic acid with two… More

Smart Probes for Imaging Cancer

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard T. Hamilton
Award Amount: $214,000.00
Abstract:
DESCRIPTION (provided by applicant): Detection and treatment of cancer can be greatly facilitated by noninvasive in vivo imaging techniques. In vivo imaging methods are most effective if they can be seamlessly tied to therapies. We propose to develop a novel imaging system using allosteric… More

Aptamers for Imaging and Therapy

Award Year / Program / Phase: 2006 / STTR / Phase II
Agency: HHS
Research Institution: Iowa State Univ
Principal Investigator: Richard T. Hamilton
Award Amount: $1,349,935.00
RI Contact: N/A
Abstract:
DESCRIPTION (provided by applicant): Phase I The current proposal describes the selection of an aptamer that recognizes the drug PD173955, which is one of large family of substituted pyrido[2,3-d]pyrimidine inhibitors of tyrosine protein kinases. An aptamer is a single stranded nucleic acid that… More

Early diagnosis of acute kidney injury by aptasensors

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Muslum Ilgu – 515-292-5141
Award Amount: $150,501.00
Abstract:
DESCRIPTION (provided by applicant): Acute kidney injury (AKI) affects more than 10 million people worldwide each year with reported mortalities from 15 to 60% in different patient populations. However, methods are lacking to support the early diagnosis ofAKI that could lead to early intervention,… More