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A NOVEL SCREEN FOR INHIBITORS OF FUNGAL GPI-ANCHORING

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60441
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
AI048337
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MYCOLOGICS, INC.
MYCOLOGICS, INC. 12635 E. MONTVIEW BLVD AURORA, CO 80045
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: A NOVEL SCREEN FOR INHIBITORS OF FUNGAL GPI-ANCHORING
Agency: HHS
Contract: 1R43AI048337-01A2
Award Amount: $100,000.00
 

Abstract:

Perhaps the most striking difference between fungal cells and human cells is that fungal cells are encased in a wall that protects them from a hostile external environment. The cell wall plays a dynamic role in all aspects of fungal physiology. The fact that human cells lack a cell wall and the underlying biosynthetic and regulatory machinery to make the wall, suggests that drugs targeting cell-wall synthesis and assembly will be safe and specific antifungals. Current treatments include Amphotericin B and a variety of azoles that inhibit membrane-sterol biosynthesis. Unfortunately, Amphotericin B is toxic to humans and clinical resistance to azoles is increasing. These observations underscore the clear need for new antifungals. In this Phase I SBIR application, we propose to develop a novel screen that targets an essential step in fungal cell-wall assembly, namely, the extracellular anchorage of GPI-class mannoproteins. This will be accomplished in two specific aims: 1). Development of a screen to detect inhibitors of GPI-mannoprotein anchoring into the cell wall; 2). Screening of extracts for inhibitors using the assay developed in Aim One.

Principal Investigator:

Claude P. Selitrennikoff
3033158647
CLAUDE.SELITRENNIKOFF@UCHSC.EDU

Business Contact:

Claude Selitrennikoff
7208594190
CLAUDE.SELITRENNIKOFF@UCHSC.EDU
Small Business Information at Submission:

MYCOLOGICS, INC.
MYCOLOGICS, INC. 12635 E MONTVIEW BLVD AURORA, CO 80010

EIN/Tax ID: 841501938
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No