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A NOVEL SCREEN FOR INHIBITORS OF FUNGAL GPI-ANCHORING
- Small Business Information
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Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 1
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Fiscal Year: 2002Title: A NOVEL SCREEN FOR INHIBITORS OF FUNGAL GPI-ANCHORINGAgency: HHSContract: 1R43AI048337-01A2Award Amount: $100,000.00
Abstract:
Perhaps the most striking difference between fungal cells and human cells is that fungal cells are encased in a wall that protects them from a hostile external environment. The cell wall plays a dynamic role in all aspects of fungal physiology. The fact that human cells lack a cell wall and the underlying biosynthetic and regulatory machinery to make the wall, suggests that drugs targeting cell-wall synthesis and assembly will be safe and specific antifungals. Current treatments include Amphotericin B and a variety of azoles that inhibit membrane-sterol biosynthesis. Unfortunately, Amphotericin B is toxic to humans and clinical resistance to azoles is increasing. These observations underscore the clear need for new antifungals. In this Phase I SBIR application, we propose to develop a novel screen that targets an essential step in fungal cell-wall assembly, namely, the extracellular anchorage of GPI-class mannoproteins. This will be accomplished in two specific aims: 1). Development of a screen to detect inhibitors of GPI-mannoprotein anchoring into the cell wall; 2). Screening of extracts for inhibitors using the assay developed in Aim One.Small Business Information at Submission:MYCOLOGICS, INC.
MYCOLOGICS, INC. 12635 E MONTVIEW BLVD AURORA, CO 80010EIN/Tax ID: 841501938DUNS: N/ANumber of Employees: N/AWoman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
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Agency: Department of Health and Human Services |
Branch: N/A |
Award ID: 60441 |
Program Year/Program: 2002 / SBIR |
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Agency Tracking Number: AI048337 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |